A
Alice Laughlin
Researcher at University of Pennsylvania
Publications - 10
Citations - 1650
Alice Laughlin is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Gut flora & Deep sequencing. The author has an hindex of 8, co-authored 10 publications receiving 1323 citations.
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Journal ArticleDOI
Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota.
Lindsey Albenberg,Tatiana V. Esipova,Colleen Judge,Kyle Bittinger,Jun Chen,Alice Laughlin,Stephanie Grunberg,Robert N. Baldassano,James D. Lewis,Hongzhe Li,Stephen R. Thom,Frederic D. Bushman,Sergei A. Vinogradov,Gary D. Wu +13 more
TL;DR: A radial gradient of microbes linked to the distribution of oxygen and nutrients provided by host tissue is observed in an analysis of intestinal microbiota of mice and human beings.
Journal ArticleDOI
Comparison of placenta samples with contamination controls does not provide evidence for a distinct placenta microbiota.
Abigail Lauder,Aoife M. Roche,Scott Sherrill-Mix,Aubrey Bailey,Alice Laughlin,Kyle Bittinger,Rita Leite,Michal A. Elovitz,Samuel Parry,Frederic D. Bushman +9 more
TL;DR: This sample set could not distinguish between placental samples and contamination introduced during DNA purification, and no placental bacterial lineages were shared between extraction methods, though oral and vaginal samples showed characteristic, distinctive composition.
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Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation
Lisa C. Osborne,Laurel A. Monticelli,Timothy J. Nice,Tara E. Sutherland,Mark C. Siracusa,Matthew R. Hepworth,Vesselin T. Tomov,Dmytro Kobuley,Sara Tran,Kyle Bittinger,Aubrey Bailey,Alice Laughlin,Jean-Luc Boucher,E. John Wherry,Frederic D. Bushman,Judith E. Allen,Herbert W. Virgin,David Artis +17 more
TL;DR: Data indicate that helminth-induced immunomodulation occurs independently of changes in the microbiota but is dependent on Ym1, a chitinase-like molecule that is associated with alternatively activated macrophages, which could partially restore antiviral immunity.
Journal ArticleDOI
Composition and dynamics of the respiratory tract microbiome in intubated patients
Brendan J Kelly,Ize Imai,Kyle Bittinger,Alice Laughlin,Barry D. Fuchs,Frederic D. Bushman,Ronald G. Collman +6 more
TL;DR: Longitudinal analysis of respiratory tract microbiota in critically ill patients provides insight into the pathogenesis and diagnosis of LRTI and holds promise for expanded pathogen identification.
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Improved characterization of medically relevant fungi in the human respiratory tract using next-generation sequencing
Kyle Bittinger,Emily S. Charlson,Elizabeth Loy,David J Shirley,Andrew R. Haas,Alice Laughlin,Yanjie Yi,Gary D. Wu,James D. Lewis,Ian Frank,Edward Cantu,Joshua M. Diamond,Jason D. Christie,Ronald G. Collman,Frederic D. Bushman +14 more
TL;DR: Using an improved method for contamination filtering, it is possible to characterize fungal communities in the human respiratory tract more accurately and explore their interactions with bacterial communities in health and disease.