A
Alicia Rodríguez-Gascón
Researcher at University of the Basque Country
Publications - 59
Citations - 2008
Alicia Rodríguez-Gascón is an academic researcher from University of the Basque Country. The author has contributed to research in topics: Medicine & Gene delivery. The author has an hindex of 19, co-authored 52 publications receiving 1419 citations.
Papers
More filters
Journal ArticleDOI
Applications of lipid nanoparticles in gene therapy.
TL;DR: The potential of solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) for gene therapy has been discussed in this article, including the main advances in their application for the treatment of ocular diseases, infectious diseases, lysosomal storage disorders and cancer.
Journal ArticleDOI
Dextran-protamine coated nanostructured lipid carriers as mucus-penetrating nanoparticles for lipophilic drugs.
TL;DR: This is the first time that Dex-Prot coating has been described as a nanoparticle muco-penetration enhancer across the intestinal mucus barrier, and thus, an efficient nanoparticle oral delivery.
Journal ArticleDOI
Structural recovery of the retina in a retinoschisin-deficient mouse after gene replacement therapy by solid lipid nanoparticles
P. S. Apaolaza,A. del Pozo-Rodríguez,María Ángeles Solinís,Jose M. Rodriguez,Ulrike Friedrich,Josune Torrecilla,Bernhard H. F. Weber,Alicia Rodríguez-Gascón +7 more
TL;DR: The structural improvement of the retina of Rs1h-deficient mice with PR specific expression of the RS1 gene driven by the specific promoter mOPS is shown, after successful delivery via SLN-based non-viral vectors.
Journal ArticleDOI
Development of nucleic acid vaccines: use of self-amplifying RNA in lipid nanoparticles
TL;DR: The concept of self-amplifying RNA vaccines and the most promising lipid-based delivery systems are discussed and they are shown to be potent in several animal species, including mice, nonhuman primates, and humans.
Journal ArticleDOI
Lipid nanoparticles as carriers for RNAi against viral infections: current status and future perspectives.
TL;DR: This review features the current application of LNP in RNAi mediated therapy against viral infections and aims to explore possible future lines of action in this field.