J
Josune Torrecilla
Researcher at University of the Basque Country
Publications - 9
Citations - 278
Josune Torrecilla is an academic researcher from University of the Basque Country. The author has contributed to research in topics: RNA interference & Gene silencing. The author has an hindex of 7, co-authored 9 publications receiving 220 citations.
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Journal ArticleDOI
Structural recovery of the retina in a retinoschisin-deficient mouse after gene replacement therapy by solid lipid nanoparticles
P. S. Apaolaza,A. del Pozo-Rodríguez,María Ángeles Solinís,Jose M. Rodriguez,Ulrike Friedrich,Josune Torrecilla,Bernhard H. F. Weber,Alicia Rodríguez-Gascón +7 more
TL;DR: The structural improvement of the retina of Rs1h-deficient mice with PR specific expression of the RS1 gene driven by the specific promoter mOPS is shown, after successful delivery via SLN-based non-viral vectors.
Journal ArticleDOI
Lipid nanoparticles as carriers for RNAi against viral infections: current status and future perspectives.
TL;DR: This review features the current application of LNP in RNAi mediated therapy against viral infections and aims to explore possible future lines of action in this field.
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Solid lipid nanoparticle-based vectors intended for the treatment of X-linked juvenile retinoschisis by gene therapy: In vivo approaches in Rs1h-deficient mouse model.
P. S. Apaolaza,A. del Pozo-Rodríguez,Josune Torrecilla,Alicia Rodríguez-Gascón,Jose M. Rodriguez,Ulrike Friedrich,Bernhard H. F. Weber,María Ángeles Solinís +7 more
TL;DR: In vitro and in vivo evaluation of two different non-viral vectors based on solid lipid nanoparticles, protamine and two anionic polysaccharides, hyaluronic acid (HA) or dextran, for the treatment of X-linked juvenile retinoschisis shows for the first time a successful RS1 gene transfer to Rs1h-deficient animals using non-Viral nanocarriers, with promising results.
Journal ArticleDOI
Solid lipid nanoparticles as non-viral vector for the treatment of chronic hepatitis C by RNA interference.
Josune Torrecilla,Ana del Pozo-Rodríguez,P. S. Apaolaza,María Ángeles Solinís,Alicia Rodríguez-Gascón +4 more
TL;DR: Vectors prepared with HA showed to be twice more effective than those prepared with DX, and differences in the intracellular trafficking may justify the higher efficacy of the HA-prepared vectors.
Journal ArticleDOI
Gene delivery in the cornea: in vitro & ex vivo evaluation of solid lipid nanoparticle-based vectors.
Mónica Vicente-Pascual,Andrea Albano,Andrea Albano,María Ángeles Solinís,Loredana Serpe,Alicia Rodríguez-Gascón,Federica Foglietta,Elisabetta Muntoni,Josune Torrecilla,Ana del Pozo-Rodríguez,Luigi Battaglia +10 more
TL;DR: Solid lipid nanoparticle-based vectors are promising gene delivery systems for corneal diseases, including inflammation.