Alicja Lerner

TL;DR: Replicated studies have demonstrated that the SERT 5'-flanking region polymorphism SS genotype is associated with poorer therapeutic responses and more frequent serious side effects during treatment with antidepressant SERT antagonists, namely, the serotonin reuptake inhibitors (SRIs).

TL;DR: Results are consistent with the longstanding hypothesis that circuits involving the basal ganglia and thalamus are disinhibited in Tourette syndrome patients, and abnormalities in GABA(A) receptor binding in the insula and cerebellum appear particularly noteworthy based upon recent evidence implicating these structures in the generation of tics.

TL;DR: Overactivity of SI is more dramatic and suggests a primary deficit in processing sensory feedback in writer's cramp, which may arise in part as a dysfunction of sensory circuits, which causes defective sensorimotor integration resulting in co-contractions of muscles and overflow phenomena.

TL;DR: It is indicated that [18F]fallypride is useful for measuring amphetamine‐induced dopamine release, but may be unreliable for estimating tonic dopamine levels, in striatum and extrastriatal regions of healthy humans.

TL;DR: Results suggest a central role for the insula possibly together with ACC in suppression of blinking and prominent activation of bilateral insular-claustrum regions.