Vanessa Cropley

TL;DR: The present study provides a robust profile of widespread WM abnormalities in schizophrenia patients worldwide, and is believed to be the first ever large-scale coordinated study of WM microstructural differences in schizophrenia.

TL;DR: Although associations between DA and cognitive measures need to be considered within the context of fronto-striato-thalamic circuitry, it is suggested that striatal DA activity, particularly via D2 receptors, might be important for response inhibition, temporal organization of material, and motor performance, whereas cortical DA transmission via D1 receptors might beimportant for maintaining and representing on-going behavior.

TL;DR: In monkey and rat, 3 and 10 were rapidly metabolized by ester hydrolysis and N-debenzylation, respectively, each to a single polar radiometabolite, and are effective for imaging PBR in monkey brain.

TL;DR: Evidence for microglial dysfunction in schizophrenia is reviewed from both neuroimaging and neuropathological data, with a specific focus on studies examining microglia activation in relation to the pathology of grey and white matter.

TL;DR: The findings suggest that schizophrenia is characterized by an initial, rapid rate of gray matter loss that slows in middle life, followed by the emergence of a deficit in white matter that progressively worsens with age at a constant rate.