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Alina Franzen
Researcher at University of Bonn
Publications - 16
Citations - 377
Alina Franzen is an academic researcher from University of Bonn. The author has contributed to research in topics: Head and neck squamous-cell carcinoma & Primary tumor. The author has an hindex of 9, co-authored 10 publications receiving 330 citations. Previous affiliations of Alina Franzen include Anschutz Medical Campus.
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Journal ArticleDOI
FGFR1 Expression Levels Predict BGJ398 Sensitivity of FGFR1-Dependent Head and Neck Squamous Cell Cancers.
Friederike Göke,Alina Franzen,Trista K. Hinz,Lindsay Marek,Petros Yoon,Rakesh Sharma,Maike Bode,Anne Von Maessenhausen,Brigitte Lankat-Buttgereit,Antonia Göke,Carsten Golletz,Robert Kirsten,Diana Boehm,Wenzel Vogel,Emily K. Kleczko,Justin R. Eagles,Fred R. Hirsch,Tobias van Bremen,Friedrich Bootz,Andreas Schroeck,Jihye Kim,Aik Choon Tan,Antonio Jimeno,Lynn E. Heasley,Sven Perner +24 more
TL;DR: The results support FGFR1 mRNA or protein expression, rather thanFGFR1 CNG as a predictive biomarker for the response to FGFR inhibitors in a subset of patients suffering from HNSCC.
Journal ArticleDOI
Expression and role of the embryonic protein SOX2 in head and neck squamous cell carcinoma
Andreas Schröck,Maike Bode,Friederike Göke,Petra M. Bareiss,Rebekka Schairer,Hui Wang,Wilko Weichert,Alina Franzen,Robert Kirsten,Tobias van Bremen,Angela Queisser,Glen Kristiansen,Lynn E. Heasley,Friedrich Bootz,Claudia Lengerke,Sven Perner +15 more
TL;DR: Functionally, SOX2 induced the expression of the antiapoptotic protein BCL-2 and enhanced resistance to apoptosis-inducing agents including cisplatin, indicatingSOX2 as a mediator of therapy resistance in human HNSCC.
Journal ArticleDOI
Fibroblast growth factor receptor 1 amplification is a common event in squamous cell carcinoma of the head and neck.
Friederike Göke,Maike Bode,Alina Franzen,Robert Kirsten,Diane Goltz,Antonia Göke,Rakesh Sharma,Diana Boehm,Wenzel Vogel,Patrick L. Wagner,Claudia Lengerke,Glen Kristiansen,Jutta Kirfel,Tobias van Bremen,Friedrich Bootz,Lynn E. Heasley,Andreas Schröck,Sven Perner +17 more
TL;DR: The data identify fibroblast growth factor receptor 1 amplification as a frequent event in primary and metastatic head and neck squamous cell carcinoma and represents a potential biomarker for more aggressive disease.
Journal ArticleDOI
Rationale for Treatment of Metastatic Squamous Cell Carcinoma of the Lung Using Fibroblast Growth Factor Receptor Inhibitors
Friederike Göke,Alina Franzen,Roopika Menon,Diane Goltz,Robert Kirsten,Diana Boehm,Wenzel Vogel,Antonia Göke,Veit Scheble,J. Ellinger,Ulrich Gerigk,Falko Fend,Patrick L. Wagner,Andreas Schroeck,Sven Perner +14 more
TL;DR: It is suggested that the FGFR1 amplification is a clonal event in tumor progression and carry potential therapeutic implications in that small-molecule inhibitors may be applicable to the treatment of a subset of patients with metastatic L-SCC.
Journal ArticleDOI
Sex determining region Y-box 2 (SOX2) amplification is an independent indicator of disease recurrence in sinonasal cancer.
Andreas Schröck,Friederike Göke,Patrick L. Wagner,Maike Bode,Alina Franzen,Martin Braun,Sebastian Huss,Abbas Agaimy,Stephan Ihrler,Ropika Menon,Robert Kirsten,Glen Kristiansen,Friedrich Bootz,Claudia Lengerke,Sven Perner +14 more
TL;DR: SNUCs are molecularly closely related to SCCs and INVCs and that these entities represent a subgroup of sinonasal carcinomas relying on SOX2 acquisition during oncogenesis, suggesting that these patients might benefit from a more aggressive therapy regime.