Falko Fend

TL;DR: The combined action of the T-helper-1-cell cytokines IFN-γ and tumour necrosis factor (TNF) directly induces permanent growth arrest in cancers, a general mechanism for arresting cancer progression.

TL;DR: The findings demonstrate that germ-line mutations in p27Kip1 can predispose to the development of multiple endocrine tumors in both rats and humans.

TL;DR: The definition, recommended studies, and criteria for the diagnosis of many entities have been extensively refined and some categories considered provisional are now upgraded to definite entities in the proposed International Consensus Classification of mature lymphoid, histiocytic, and dendritic cell tumors.

TL;DR: Laser capture microdissection (LCM) is state-of-the-art technology that provides the scientific community with a rapid and reliable method to isolate a homogeneous population of cells from heterogeneous tissue specimens, thus providing investigators with the ability to analyze DNA, RNA, and protein accurately from pure populations of cells.

TL;DR: It is concluded that constitutive activation of the PI3K/Akt pathway contributes to the pathogenesis of MCL and preferentially occurs in blastoid variants and one possible mechanism of activation is loss of PTEN expression.