Aline Van Acker

TL;DR: In this paper, the effects of Prostaglandin (PG) E2 on human ILC2 proliferation and intracellular cytokine and transcription factor expression were assessed by means of flow cytometry.

TL;DR: It is revealed that endogenously produced PGD2 is essential in cytokine-induced ILC2 activation because blocking of the COX-1/2 or HPGDS enzymes or the CRTH2 receptor abolishes I LC2 responses.

TL;DR: It is found that Ikaros (IKZF1) is expressed by all ILC subsets, including NK cells, in blood, tonsil, and gut, while Helios (IKzF2) is preferentially expressed by ILC3 in tonsil and Gut, suggesting new possibilities in targeting IkarOS family TFs for modulation of type 1/3 immunity in inflammation and cancer.

TL;DR: It is shown that Ly49E expression is very low on known ILC populations, but it can be used to define a previously unrecognized intraepithelial innate lymphoid population, suggesting that this previously unrecognize population may contribute to Th1-mediated immunity.

TL;DR: Results show that bone marrow and splenic NK cells are present in normal numbers in Ly49E KO mice, expressing an unaltered panel of NKRs and differentiation markers, and cytokine production and cytotoxicity by these cells are unaffected.