T
Tom Taghon
Researcher at Ghent University
Publications - 143
Citations - 6338
Tom Taghon is an academic researcher from Ghent University. The author has contributed to research in topics: T cell & Cellular differentiation. The author has an hindex of 36, co-authored 123 publications receiving 4952 citations. Previous affiliations of Tom Taghon include California Institute of Technology & Ghent University Hospital.
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Journal ArticleDOI
A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia
Apostolos Klinakis,Camille Lobry,Omar Abdel-Wahab,Philmo Oh,Hiroshi Haeno,Silvia Buonamici,Silvia Buonamici,Inge Van de Walle,Séverine Cathelin,Thomas Trimarchi,Elisa Araldi,Cynthia Liu,Sherif Ibrahim,M. Beran,Jiri Zavadil,Argiris Efstratiadis,Tom Taghon,Franziska Michor,Ross L. Levine,Iannis Aifantis +19 more
TL;DR: A novel role for Notch signalling is identified during early haematopoietic stem cell differentiation and it is suggested that the Notch pathway can play both tumour-promoting and -suppressive roles within the same tissue.
Journal ArticleDOI
A cell atlas of human thymic development defines T cell repertoire formation.
Jong-Eun Park,Rachel A. Botting,Cecilia Domínguez Conde,Dorin-Mirel Popescu,Marieke Lavaert,Daniel J Kunz,Daniel J Kunz,Daniel J Kunz,Issac Goh,Emily Stephenson,Roberta Ragazzini,Roberta Ragazzini,Elizabeth Tuck,Anna Wilbrey-Clark,Kenny Roberts,Veronika R. Kedlian,John R. Ferdinand,Xiaoling He,Simone Webb,Daniel Maunder,Niels Vandamme,Krishnaa T. Mahbubani,Krzysztof Polanski,Lira Mamanova,Liam Bolt,David Crossland,David Crossland,Fabrizio De Rita,Andrew Fuller,Andrew Filby,Gary Reynolds,David Dixon,Kourosh Saeb-Parsy,Steven Lisgo,Deborah J. Henderson,Roser Vento-Tormo,Omer Ali Bayraktar,Roger A. Barker,Kerstin B. Meyer,Yvan Saeys,Paola Bonfanti,Paola Bonfanti,Sam Behjati,Sam Behjati,Menna R. Clatworthy,Menna R. Clatworthy,Menna R. Clatworthy,Tom Taghon,Muzlifah Haniffa,Muzlifah Haniffa,Sarah A. Teichmann,Sarah A. Teichmann +51 more
TL;DR: The authors' single-cell transcriptome profile of the thymus across the human lifetime and across species provides a high-resolution census of T cell development within the native tissue microenvironment, and identifies novel subpopulations of human thymic fibroblasts and epithelial cells and located them in situ.
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Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche
Johnny Bonnardel,Wouter T’Jonck,Djoere Gaublomme,Robin Browaeys,Charlotte L. Scott,Liesbet Martens,Bavo Vanneste,Sofie De Prijck,Sergei A. Nedospasov,Anna Kremer,Evelien Van Hamme,Peter Borghgraef,Wendy Toussaint,Pieter De Bleser,Inge Mannaerts,Alain Beschin,Leo A. van Grunsven,Bart N. Lambrecht,Tom Taghon,Saskia Lippens,Dirk Elewaut,Yvan Saeys,Martin Guilliams +22 more
TL;DR: It is shown that the Kupffer cell niche is composed of stellate cells, hepatocytes, and endothelial cells that together imprint the liver-specific macrophage identity.
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Developmental and Molecular Characterization of Emerging β- and γδ-Selected Pre-T Cells in the Adult Mouse Thymus
TL;DR: It is shown that CD27 is upregulated in DN3 thymocytes initiating β selection, concomitant with intracellular TCR-β expression, which generates CD4^+CD8^+ progeny with more than 90% efficiency, faster and more efficiently than the CD27^(low) majority.
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PHF6 mutations in T-cell acute lymphoblastic leukemia
Pieter Van Vlierberghe,Pieter Van Vlierberghe,Pieter Van Vlierberghe,Teresa Palomero,Hossein Khiabanian,Joni Van der Meulen,Mireia Castillo,Nadine Van Roy,Barbara De Moerloose,Jan Philippé,Sara González-García,María L. Toribio,Tom Taghon,Linda Zuurbier,Barbara Cauwelier,Christine J. Harrison,Claire Schwab,Markus Pisecker,Sabine Strehl,Anton W. Langerak,Jozef Gecz,Edwin Sonneveld,Rob Pieters,Elisabeth Paietta,Jacob M. Rowe,Peter H. Wiernik,Yves Benoit,Jean Soulier,Bruce Poppe,Xiaopan Yao,Carlos Cordon-Cardo,Jules P.P. Meijerink,Raul Rabadan,Frank Speleman,Adolfo A. Ferrando +34 more
TL;DR: PHF6 is identified as a new X-linked tumor suppressor in T-ALL and a strong genetic interaction between PHF6 loss and aberrant expression of TLX transcription factors in the pathogenesis of this disease is pointed to.