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Alison D. O'Brien
Researcher at Uniformed Services University of the Health Sciences
Publications - 195
Citations - 19269
Alison D. O'Brien is an academic researcher from Uniformed Services University of the Health Sciences. The author has contributed to research in topics: Escherichia coli & Shiga toxin. The author has an hindex of 73, co-authored 194 publications receiving 18602 citations. Previous affiliations of Alison D. O'Brien include Albert Einstein College of Medicine & Bristol Royal Infirmary.
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Plants and plant cells expressing histidine tagged intimin
TL;DR: In this article, the authors proposed the use of transgenic plants as vehicles for stimulating a protective immune response against EHEC and the one or more other antigens, expressed by transgenetic plants.
Book ChapterDOI
Plant and Bacterial Toxins as RNA N-Glycosidases
TL;DR: It is shown that when four different RIPs were highly purified, the only enzymatic activity they retained was the capacity to remove adenine from rRNA or DNA, indicating that the RIPs, originally defined as RNA N-glycosidases, are actually polynucleotide:adenosine glycosidase, at least in vitro.
ComponentDOI
Shiga toxin type 2
Marie E. Fraser,Masao Fujinaga,Maia M. Cherney,Angela R. Melton-Celsa,Edda M. Twiddy,Alison D. O'Brien,Michael N.G. James +6 more
Book ChapterDOI
Characterization of Monoclonal Antibodies Which Recognize Specific Cell Surface Determinants on Salmonella Typhimurium
TL;DR: Murine typhoid, a naturally occurring disease in mice caused by Salmonella typhimurium, is a good experimental model with which to study the interactions between host and parasite and is especially important since the pathogenesis of this disease is similar to typhoid fever in man.
Book ChapterDOI
Shiga Toxins (Stxs): Multifaceted Pathogenicity Determinants
TL;DR: The Shiga toxins (Stxs) constitute a family of toxins that features Stx from Shigella dysenteriae type 1 as the prototype, which are particularly potent poisons that are estimated to be as toxic per unit of weight as tetanus toxin and second only to botulinum toxin in potency.