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Alison D. O'Brien
Researcher at Uniformed Services University of the Health Sciences
Publications - 195
Citations - 19269
Alison D. O'Brien is an academic researcher from Uniformed Services University of the Health Sciences. The author has contributed to research in topics: Escherichia coli & Shiga toxin. The author has an hindex of 73, co-authored 194 publications receiving 18602 citations. Previous affiliations of Alison D. O'Brien include Albert Einstein College of Medicine & Bristol Royal Infirmary.
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Two domains of cytotoxic necrotizing factor type 1 bind the cellular receptor, laminin receptor precursor protein.
TL;DR: CNF1 contains two major binding regions: one located within the N terminus, which contained amino acids 135 to 164, and one which resided in the C terminus and included amino acids 683 to 730, which indicates that CNF1 can bind to an additional receptor on HEp-2 cells and that LRP can also serve as a cellular receptor for CNF2.
Journal Article
Additional evidence that the Lps gene locus regulates natural resistance to S. typhimurium in mice.
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Epitope mapping of monoclonal antibodies capable of neutralizing cytotoxic necrotizing factor type 1 of uropathogenic Escherichia coli.
TL;DR: These findings identify three new regions of the toxin that appear to be critical for the biological activity of CNF1, including the binding and enzymatic domains.
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Escherichia coli O157:H7 infection in dutch belted and New Zealand white rabbits
Aruna Panda,Ivan Tatarov,Angela R. Melton-Celsa,Krishnan Kolappaswamy,Edwin H. Kriel,Daniel Petkov,Turhan Coksaygan,Sofie Livio,Charles G. McLeod,James P. Nataro,Alison D. O'Brien,Louis J. DeTolla +11 more
TL;DR: Evidence is provided that both breeds of rabbits are susceptible to E. coli O157:H7 infection and that both may be useful models for investigating EHEC infections of humans, and both breeds developed clinical signs of disease and intestinal lesions after experimental infection.
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Antibody against the Carboxyl Terminus of Intimin α Reduces Enteropathogenic Escherichia coli Adherence to Tissue Culture Cells and Subsequent Induction of Actin Polymerization
TL;DR: It is observed that the adherence of EPEC strains to HEp-2 cells was reduced and that actin polymerization was blocked by antibody raised against the C-terminal third of intimin α.