A
Alison D. O'Brien
Researcher at Uniformed Services University of the Health Sciences
Publications - 195
Citations - 19269
Alison D. O'Brien is an academic researcher from Uniformed Services University of the Health Sciences. The author has contributed to research in topics: Escherichia coli & Shiga toxin. The author has an hindex of 73, co-authored 194 publications receiving 18602 citations. Previous affiliations of Alison D. O'Brien include Albert Einstein College of Medicine & Bristol Royal Infirmary.
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Journal ArticleDOI
Virulence of the Shiga Toxin Type 2-Expressing Escherichia coli O104:H4 German Outbreak Isolate in Two Animal Models
Tonia Zangari,Angela R. Melton-Celsa,Aruna Panda,Nadia Boisen,Mark A. Smith,Ivan Tatarov,Louis J. De Tolla,James P. Nataro,Alison D. O'Brien +8 more
TL;DR: Two animal models for EAEC pathogenesis are described and studies show that Stx2 is responsible for most of the virulence observed in C227-11-infected mice and rabbits.
Journal ArticleDOI
Identification of three amino acid residues in the B subunit of Shiga toxin and Shiga-like toxin type II that are essential for holotoxin activity.
TL;DR: Comparable mutations induced in the B-subunit gene of Shiga toxin by oligonucleotide-directed, site-specific mutagenesis resulted in drastically decreased cytotoxicity as compared with that of wild-type Shigella dysenteriae type I.
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Production of a Shiga-like cytotoxin by Campylobacter
TL;DR: The data indicate that low levels of Shiga-like toxin are produced by some Campylobacter isolates but that SLT is genetically distinct from the SLT-I toxin produced at high levels by certain E. coli strains.
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The Presence of the pAA Plasmid in the German O104:H4 Shiga Toxin Type 2a (Stx2a)–Producing Enteroaggregative Escherichia coli Strain Promotes the Translocation of Stx2a Across an Epithelial Cell Monolayer
Nadia Boisen,Anne-Marie Hansen,Angela R. Melton-Celsa,Tonia Zangari,Ninell P. Mortensen,Ninell P. Mortensen,James B. Kaper,Alison D. O'Brien,James P. Nataro +8 more
TL;DR: The data suggest that the AggR-regulated aggregative adherence fimbriae I enhance inflammation and enable the outbreak strain to both adhere to epithelial cells and translocate Stx2a across the intestinal epithelium.
Journal ArticleDOI
Position on Mouse Chromosome 1 of a Gene that Controls Resistance to Salmonella typhimurium
B. A. Taylor,Alison D. O'Brien +1 more
TL;DR: A five-point backcross clearly showed that the correct gene order on chromosome 1 is fz-Idh-1-Ity-ln-Pep-3, which regulates the magnitude of Salmonella typhimurium growth in murine tissues and, hence, the innate salmonella resistance of mice.