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Alison D. O'Brien
Researcher at Uniformed Services University of the Health Sciences
Publications - 195
Citations - 19269
Alison D. O'Brien is an academic researcher from Uniformed Services University of the Health Sciences. The author has contributed to research in topics: Escherichia coli & Shiga toxin. The author has an hindex of 73, co-authored 194 publications receiving 18602 citations. Previous affiliations of Alison D. O'Brien include Albert Einstein College of Medicine & Bristol Royal Infirmary.
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Escherichia coli O157:H7 in beef cattle presented for slaughter in the U.S.: Higher prevalence rates than previously estimated
TL;DR: In 1983, Karmali et al. discovered an association between infection with E. coli that produce Shiga toxin, including O157:H7 strains, and another severe and sometimes fatal condition, the hemolytic uremic syndrome (HUS).
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Cytotoxic Necrotizing Factor Type 1 of Uropathogenic Escherichia coli Kills Cultured Human Uroepithelial 5637 Cells by an Apoptotic Mechanism
TL;DR: If the results with 5637 cells reflect the interaction of CNF1 with the transitional uroepithelium in the human bladder, then C NF1 may be involved in the exfoliative process that occurs in that organ after infection with uropathogenic E. coli.
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Evaluation of the role of Shiga and Shiga-like toxins in mediating direct damage to human vascular endothelial cells.
TL;DR: The relative resistance of EC to Shiga toxin and Shiga-like toxins may be due to reduced toxin binding, as low levels of globotriaosylceramide (Gb3), the toxin-specific receptor, were found in EC membranes.
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Purification of shigella dysenteriae 1 (shiga)-like toxin from escherichia coli 0157:h7 strain associated with haemorrhagic colitis
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Flagellar phase variation of Salmonella enterica serovar Typhimurium contributes to virulence in the murine typhoid infection model but does not influence Salmonella-induced enteropathogenesis
Jack S. Ikeda,Clare K. Schmitt,Stephen C. Darnell,Patricia R. Watson,Jennifer Bispham,Timothy S. Wallis,Debra L. Weinstein,Eleanor S. Metcalf,Phillip Adams,C. David O'Connor,Alison D. O'Brien +10 more
TL;DR: It is suggested that phase variation is not involved in the intestinal stage of infection but that once S. enterica serovar Typhimurium reaches the spleens of susceptible mice those organisms in the FliC phase can grow and/or survive better than those in theFljB phase.