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Alison D. O'Brien
Researcher at Uniformed Services University of the Health Sciences
Publications - 195
Citations - 19269
Alison D. O'Brien is an academic researcher from Uniformed Services University of the Health Sciences. The author has contributed to research in topics: Escherichia coli & Shiga toxin. The author has an hindex of 73, co-authored 194 publications receiving 18602 citations. Previous affiliations of Alison D. O'Brien include Albert Einstein College of Medicine & Bristol Royal Infirmary.
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Journal Article
Shiga-like toxin production and attaching effacing activity of Escherichia coli associated with calf diarrhea.
Jacques Mainil,Christiane Duchesnes,S. C. Whipp,L. R. M. Marques,Alison D. O'Brien,Thomas A. Casey,H W Moon +6 more
TL;DR: Four hundred twenty-nine isolates of Escherichia coli from calves were tested for the production of HeLa cell cytotoxin(s) and none of the 5 SLT+ isolates contained genes for classic heat-labile or heat-stable enterotoxins, for K99 fimbriae, or for invasiveness; neither did any of them adhere to HeLa cells in culture.
Journal ArticleDOI
Cytotoxic necrotizing factor 1 and hemolysin from uropathogenic Escherichia coli elicit different host responses in the murine bladder.
TL;DR: Substantial roles are demonstrated for CNF1 and HlyA1 in initiation of a strong proinflammatory response to UPEC in the bladder.
Journal ArticleDOI
Decreased adherence of enterohemorrhagic Escherichia coli to HEp-2 cells in the presence of antibodies that recognize the C-terminal region of intimin.
TL;DR: It is suggested that intiminO157 could be used as an immunogen to elicit adherence-blocking antibodies against O157:H7 strains and closely-related EHEC.