A
Alison J. Thomson
Researcher at University of Edinburgh
Publications - 11
Citations - 878
Alison J. Thomson is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Stem cell & Embryonic stem cell. The author has an hindex of 9, co-authored 11 publications receiving 786 citations. Previous affiliations of Alison J. Thomson include University of Aberdeen.
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Journal ArticleDOI
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
Michael J. Devine,Mina Ryten,Petr Vodicka,Alison J. Thomson,Tom Burdon,Henry Houlden,Fatima Cavaleri,Masumi Nagano,Masumi Nagano,Nicola J. Drummond,Jan-Willem Taanman,Anthony H.V. Schapira,Katrina Gwinn,John Hardy,Patrick A. Lewis,Tilo Kunath +15 more
TL;DR: This model represents a new experimental system to identify compounds that reduce levels of α- synuclein, and to investigate the mechanistic basis of neurodegeneration caused by α-synuclein dysfunction.
Journal ArticleDOI
Infection efficiency of human and mouse embryonic stem cells using adenoviral and adeno-associated viral vectors.
Joseph R. Smith-Arica,Alison J. Thomson,Ray Ansell,John A. Chiorini,Beverly L. Davidson,Jim McWhir +5 more
TL;DR: Investigation of infection of human and mouse embryonic stem cells with two of the most popular vectors in gene transfer, adenovirus type 5 (Ad5) and adeno-associated virus (AAV; serotypes 2, 4, and 5) shows that Ad5- and AAV2-based vectors are capable of infecting both human andmouse ES cells, in both their undifferentiated and differentiated states.
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Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Csf1r Locus.
Clare Pridans,Anna Raper,Gemma M. Davis,Joana Alves,Kristin A. Sauter,Lucas Lefevre,Tim Regan,Stephen Meek,Linda Sutherland,Alison J. Thomson,Sara Clohisey,Stephen J. Bush,Stephen J. Bush,Rocio Rojo,Zofia M. Lisowski,Robert Wallace,Kathleen Grabert,Kyle R. Upton,Kyle R. Upton,Yi Ting Tsai,Deborah Brown,Lee B. Smith,Lee B. Smith,Kim M. Summers,Neil A. Mabbott,Pedro Piccardo,Michael Cheeseman,Tom Burdon,David A. Hume +28 more
TL;DR: The results highlight the redundant and nonredundant functions of CSF1R signaling and of macrophages in development, organogenesis, and homeostasis.
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Bone tissue formation from human embryonic stem cells in vivo.
J. L. Tremoleda,Nicholas R. Forsyth,Nusrat Khan,Davina Wojtacha,Ioannis Christodoulou,B.J. Tye,S.N. Racey,S Collishaw,Virginie Sottile,Virginie Sottile,Alison J. Thomson,A.H.W.R. Simpson,Brendon Noble,Jim McWhir +13 more
TL;DR: It is demonstrated that hESCs exposed to OS factors in vitro undergo directed differentiation toward the osteogenic lineage in vivo in a similar fashion to that produced by hMSCs, which supports the potential future use of hESC-derived cells in regenerative medicine applications.
Journal ArticleDOI
Efficient gene targeting by homologous recombination in rat embryonic stem cells.
Stephen Meek,Mia Buehr,Linda Sutherland,Alison J. Thomson,John J. Mullins,Andrew J.H. Smith,Tom Burdon +6 more
TL;DR: It is demonstrated that gene modification via homologous recombination in rat ES cells is efficient, and should facilitate implementation of targeted, genetic manipulation in the rat.