T
Tim Regan
Researcher at University of Edinburgh
Publications - 29
Citations - 1068
Tim Regan is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Gene & Innate immune system. The author has an hindex of 13, co-authored 24 publications receiving 677 citations. Previous affiliations of Tim Regan include University College Cork & National University of Ireland.
Papers
More filters
Journal ArticleDOI
Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive Disorder.
Leday Ggr,Petra E. Vértes,Sylvia Richardson,Greene,Tim Regan,Shahid M. Khan,Henderson R,Tom C. Freeman,Carmine M. Pariante,Neil A. Harrison,Perry Vh,Wayne C. Drevets,Gayle M. Wittenberg,E.T. Bullmore +13 more
TL;DR: MDD was replicably associated with proinflammatory activation of the peripheral innate immune system, coupled with relative inactivation of the adaptiveimmune system, indicating the potential of transcriptional biomarkers for immunological stratification of patients with depression.
Journal ArticleDOI
Immune cell gene signatures for profiling the microenvironment of solid tumors
Ajit J. Nirmal,Tim Regan,Barbara Shih,David A. Hume,David A. Hume,Andrew H. Sims,Tom C. Freeman +6 more
TL;DR: The utility of ImSig is demonstrated through the stratification of melanoma patients into subgroups of prognostic significance and the identification of immune cells with the use of single-cell RNA-sequencing data derived from tumors.
Journal ArticleDOI
Structural and kinetic determinants of protease substrates.
John C. Timmer,Wenhong Zhu,Cristina Pop,Tim Regan,Scott J. Snipas,Alexey Eroshkin,Stefan J. Riedl,Guy S. Salvesen,Guy S. Salvesen +8 more
TL;DR: Defying the dogma that proteases cleave primarily in natively unstructured loops, it is found that both caspase-3 and GluC cleave in α-helices nearly as frequently as in extended loops.
Journal ArticleDOI
Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection
Bo Li,Bo Li,Sara Clohisey,Bing Shao Chia,Bing Shao Chia,Bo Wang,Ang Cui,Ang Cui,Thomas Eisenhaure,Lawrence D. Schweitzer,Paul Hoover,Nicholas J. Parkinson,Aharon Nachshon,Nikki Smith,Tim Regan,David Farr,Michael U. Gutmann,Syed I. A. Bukhari,Andy Law,Maya Sangesland,Irit Gat-Viks,Irit Gat-Viks,Paul Digard,Shobha Vasudevan,Daniel Lingwood,David H. Dockrell,John G. Doench,J Kenneth Baillie,Nir Hacohen,Nir Hacohen +29 more
TL;DR: A genome-wide CRISPR/Cas9 screen is performed and it is found that CMTR1, a human mRNA cap methyltransferase, is required for efficient viral cap snatching and regulation of a cell autonomous immune response, and provides synergistic protection with the influenza endonuclease inhibitor Xofluza.
Journal ArticleDOI
Identification of TLR10 as a Key Mediator of the Inflammatory Response to Listeria monocytogenes in Intestinal Epithelial Cells and Macrophages
Tim Regan,Kenneth Nally,Ruaidhrí J. Carmody,Aileen Houston,Fergus Shanahan,John MacSharry,Elizabeth Brint +6 more
TL;DR: Data indicate novel roles for TLR10 in sensing pathogenic infection in both the epithelium and macrophages and have identified L. monocytogenes as a source of ligand for the orphan receptor TLR 10.