S
Scott B. Lovitch
Researcher at Brigham and Women's Hospital
Publications - 36
Citations - 2442
Scott B. Lovitch is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: T cell & Major histocompatibility complex. The author has an hindex of 19, co-authored 35 publications receiving 1763 citations. Previous affiliations of Scott B. Lovitch include Harvard University & Washington University in St. Louis.
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Journal ArticleDOI
MHC proteins confer differential sensitivity to CTLA-4 and PD-1 blockade in untreated metastatic melanoma
Scott J. Rodig,Scott J. Rodig,Daniel Gusenleitner,Donald G. Jackson,Evisa Gjini,Anita Giobbie-Hurder,Chelsea Jin,Han Chang,Scott B. Lovitch,Christine Horak,Jeffrey S. Weber,Jason L. Weirather,Jedd D. Wolchok,Michael A. Postow,Michael A. Postow,Anna C. Pavlick,Jason Chesney,F. Stephen Hodi +17 more
TL;DR: It is shown that MHC class I expression in advanced melanoma predicted resistance to anti–CTLA-4, but not anti-PD-1, treatment, which may need MHCclass II to be effective, which explains why patients on combined therapy do better on average, with one drug overcoming the limitations of the other.
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The Coinhibitory Receptor CTLA-4 Controls B Cell Responses by Modulating T Follicular Helper, T Follicular Regulatory, and T Regulatory Cells
Peter T. Sage,Alison M. Paterson,Alison M. Paterson,Scott B. Lovitch,Arlene H. Sharpe,Arlene H. Sharpe +5 more
TL;DR: It is found that non-Tfr Treg cells could suppress B cell responses through CTLA-4 and that Treg and/or Tfr cells might downregulate B7-2 on B cells outside germinal centers as a means of suppression.
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SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase
Gaëlle Laurent,Natalie J. German,Asish K. Saha,Vincent C.J. de Boer,Michael N. Davies,Timothy R. Koves,Noah Dephoure,Frank Fischer,Gina Boanca,Bhavapriya Vaitheesvaran,Scott B. Lovitch,Arlene H. Sharpe,Irwin J. Kurland,Clemens Steegborn,Steven P. Gygi,Deborah M. Muoio,Neil B. Ruderman,Marcia C. Haigis +17 more
TL;DR: This work elucidates SIRT4 as an important regulator of lipid homeostasis, identifies MCD as a Sirtuin target, and deepens the understanding of the malonyl CoA regulatory axis.
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Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation
Noga Ron-Harel,Daniel Ditzel Santos,Daniel Ditzel Santos,Jonathan M. Ghergurovich,Peter T. Sage,Peter T. Sage,Anita Reddy,Scott B. Lovitch,Scott B. Lovitch,Noah Dephoure,F. Kyle Satterstrom,Michal Sheffer,Jessica B. Spinelli,Steven P. Gygi,Joshua D. Rabinowitz,Arlene H. Sharpe,Arlene H. Sharpe,Marcia C. Haigis +17 more
TL;DR: It is shown that naive CD4(+) T cell activation induces a unique program of mitochondrial biogenesis and remodeling that generates specialized mitochondria with enhanced one-carbon metabolism that is critical for T-cell activation and survival.
Journal ArticleDOI
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.
Alison M. Paterson,Alison M. Paterson,Scott B. Lovitch,Scott B. Lovitch,Peter T. Sage,Peter T. Sage,Vikram R. Juneja,Vikram R. Juneja,Youjin Lee,Justin D. Trombley,Justin D. Trombley,Carolina V. Arancibia-Cárcamo,Raymond A. Sobel,Alexander Y. Rudensky,Vijay K. Kuchroo,Gordon J. Freeman,Arlene H. Sharpe,Arlene H. Sharpe +17 more
TL;DR: It is demonstrated that, in contrast to CTLA-4 germline knockout mice, conditional deletion on T reg cells during adulthood confers protection from EAE and does not increase resistance to tumors.