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Allison E. Norlander
Researcher at Vanderbilt University
Publications - 32
Citations - 1545
Allison E. Norlander is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Inflammation & Angiotensin II. The author has an hindex of 12, co-authored 23 publications receiving 1036 citations. Previous affiliations of Allison E. Norlander include Vanderbilt University Medical Center.
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Journal ArticleDOI
The immunology of hypertension.
TL;DR: Recent data suggest that isolevuglandin-modified self-proteins in antigen-presenting cells are immunogenic, promoting cytokine production by the cells in which they are formed and T cell activation.
Journal ArticleDOI
Activation of Human T Cells in Hypertension: Studies of Humanized Mice and Hypertensive Humans.
Hana A. Itani,William G. McMaster,Mohamed A. Saleh,Rafal R. Nazarewicz,Tomasz Mikolajczyk,Anna M. Kaszuba,Anna Konior,Aleksander Prejbisz,Andrzej Januszewicz,Allison E. Norlander,Wei Chen,Rachel H. Bonami,Andrew F. Marshall,Greg Poffenberger,Cornelia M. Weyand,Meena S. Madhur,Daniel J. Moore,David G. Harrison,Tomasz J. Guzik +18 more
TL;DR: Human T cells become activated and invade critical end-organ tissues in response to hypertension in a humanized mouse model and an increase in circulating interleukin-17A producing CD4(+) and CD8(+) T cells that produce interferon-γ in hypertensive compared with normotensive humans is observed.
Journal ArticleDOI
Oligoclonal CD8+ T Cells Play a Critical Role in the Development of Hypertension
Daniel W. Trott,Salim R. Thabet,Annet Kirabo,Mohamed A. Saleh,Hana A. Itani,Allison E. Norlander,Jing Wu,Anna E. Goldstein,William J. Arendshorst,Meena S. Madhur,Wei Chen,Chung I. Li,Yu Shyr,David G. Harrison,David G. Harrison +14 more
TL;DR: Data suggest that in the development of hypertension, an oligoclonal population of CD8+ cells accumulates in the kidney and likely contributes to hypertension by contributing to sodium and volume retention and vascular rarefaction.
Journal ArticleDOI
Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II–Induced Hypertension
Allison E. Norlander,Mohamed A. Saleh,Nikhil Kamat,Benjamin Ko,Juan S. Gnecco,Linjue Zhu,Bethany L. Dale,Yoichiro Iwakura,Robert S. Hoover,Alicia A. McDonough,Meena S. Madhur +10 more
TL;DR: A mechanistic link by which IL-17A modulates renal sodium transport is provided and it is suggested that IL- 17A inhibition may improve renal function in hypertension and other autoimmune disorders.
Journal ArticleDOI
Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation
Mohamed A. Saleh,William G. McMaster,Jing Wu,Allison E. Norlander,Samuel A. Funt,Salim R. Thabet,Annet Kirabo,Liang Xiao,Wei Chen,Hana A. Itani,Danielle L. Michell,Tianxiao Huan,Yahua Zhang,Satoshi Takaki,Jens Titze,Daniel Levy,David G. Harrison,Meena S. Madhur +17 more
TL;DR: Bone marrow transplantation studies demonstrated that loss of LNK in hematopoietic cells is primarily responsible for the observed renal and vascular inflammation and predisposition to hypertension, and results suggest that LNK is a potential therapeutic target for hypertension and its associated kidneys and vascular sequela.