S
Satoshi Takaki
Researcher at University of Tokyo
Publications - 78
Citations - 4956
Satoshi Takaki is an academic researcher from University of Tokyo. The author has contributed to research in topics: Haematopoiesis & Stem cell. The author has an hindex of 34, co-authored 76 publications receiving 4629 citations. Previous affiliations of Satoshi Takaki include Kumamoto University.
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Journal ArticleDOI
Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice.
Asuka Naito,Sakura Azuma,Sakae Tanaka,Tsuyoshi Miyazaki,Satoshi Takaki,Kiyoshi Takatsu,Kazuki Nakao,Kenji Nakamura,Motoya Katsuki,Tadashi Yamamoto,Jun-ichiro Inoue +10 more
TL;DR: TRAF6, a member of the tumour necrosis factor receptor‐associated factor family, was first identified as a transducer ofCD40 and interleukin‐1 receptor (IL‐1R) signals based on the interaction of TRAF6 with the cytoplasmic tail of CD40 and with the IL-1R associated kinase in vitro.
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Differential signaling by lymphocyte antigen receptors
TL;DR: Evidence is outlined supporting the view that the nature of the ligand/receptor interaction directs the physical recruitment of signaling pathways differentially inside the lymphocyte and hence defines thenature of the subsequent immune response.
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Identification of Innate IL-5–Producing Cells and Their Role in Lung Eosinophil Regulation and Antitumor Immunity
Masashi Ikutani,Tsutomu Yanagibashi,Masaru Ogasawara,Koichi Tsuneyama,Seiji Yamamoto,Yuichi Hattori,Taku Kouro,Atsuko Itakura,Yoshinori Nagai,Satoshi Takaki,Kiyoshi Takatsu +10 more
TL;DR: It is shown that innate IL-5–producing cells were increased in response to tumor invasion, and their regulation of eosinophils is critical to suppress tumor metastasis and contribute to development of novel immunotherapies for cancer.
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Quantification of Self-Renewal Capacity in Single Hematopoietic Stem Cells from Normal and Lnk-Deficient Mice
Hideo Ema,Kazuhiro Sudo,Jun Seita,Azusa Matsubara,Yohei Morita,Mitsujiro Osawa,Kiyoshi Takatsu,Satoshi Takaki,Hiromitsu Nakauchi +8 more
TL;DR: Establishment of a clonal and quantitative assay for HSC function permitted demonstration that adult mouse HSCs are significantly heterogeneous in degree of multilineage repopulation and that higher repopulating potential reflects higher self-renewal activity.
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Adipose Natural Regulatory B Cells Negatively Control Adipose Tissue Inflammation
Satoshi Nishimura,Ichiro Manabe,Satoshi Takaki,Mika Nagasaki,Makoto Otsu,Hiroshi Yamashita,Junichi Sugita,Kotaro Yoshimura,Koji Eto,Issei Komuro,Takashi Kadowaki,Ryozo Nagai +11 more
TL;DR: Adipose tissue Breg cells are a naturally occurring regulatory B cell subset that maintains homeostasis within adipose tissue and that Breg cell dysfunction contributes pivotally to the progression of adipose tissues inflammation in obesity.