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Bethany L. Dale
Researcher at Vanderbilt University
Publications - 13
Citations - 460
Bethany L. Dale is an academic researcher from Vanderbilt University. The author has contributed to research in topics: T cell & Inflammation. The author has an hindex of 7, co-authored 11 publications receiving 305 citations. Previous affiliations of Bethany L. Dale include Johns Hopkins University School of Medicine & Vanderbilt University Medical Center.
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Journal ArticleDOI
Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II–Induced Hypertension
Allison E. Norlander,Mohamed A. Saleh,Nikhil Kamat,Benjamin Ko,Juan S. Gnecco,Linjue Zhu,Bethany L. Dale,Yoichiro Iwakura,Robert S. Hoover,Alicia A. McDonough,Meena S. Madhur +10 more
TL;DR: A mechanistic link by which IL-17A modulates renal sodium transport is provided and it is suggested that IL- 17A inhibition may improve renal function in hypertension and other autoimmune disorders.
Journal ArticleDOI
CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli
Hana A. Itani,Liang Xiao,Mohamed A. Saleh,Jing Wu,Mark A. Pilkinton,Bethany L. Dale,Natalia R. Barbaro,Jason D. Foss,Annet Kirabo,Kim Ramil C. Montaniel,Allison E. Norlander,Wei Chen,Ryosuke Sato,L. Gabriel Navar,Simon Mallal,Meena S. Madhur,Kenneth E. Bernstein,David G. Harrison +17 more
TL;DR: A previously undefined role of CD70 and long-lived T(EM) cells in the development of blood pressure elevation and end-organ damage that occur on delayed exposure to mild hypertensive stimuli is illustrated.
Journal ArticleDOI
A salt-sensing kinase in T lymphocytes, SGK1, drives hypertension and hypertensive end-organ damage
Allison E. Norlander,Mohamed A. Saleh,Arvind K. Pandey,Hana A. Itani,Jing Wu,Liang Xiao,Jooeun Kang,Bethany L. Dale,Slavina B. Goleva,Fanny Laroumanie,Liping Du,David G. Harrison,David G. Harrison,Meena S. Madhur,Meena S. Madhur,Meena S. Madhur +15 more
TL;DR: It is demonstrated that T cell SGK1 and NKCC1 may be novel therapeutic targets for the treatment of hypertension and identify a potentially new mechanism by which salt contributes to hypertension.
Journal ArticleDOI
Linking inflammation and hypertension via LNK/SH2B3.
Bethany L. Dale,Meena S. Madhur +1 more
TL;DR: LNK/SH2B3 is a key driver gene for human hypertension, and alteration of LNK in animal models has a profound effect on inflammation and hypertension, making it a potential therapeutic target for this disease and its devastating consequences.
Journal ArticleDOI
Critical role of Interleukin 21 and T follicular helper cells in hypertension and vascular dysfunction.
Bethany L. Dale,Arvind K. Pandey,Yuhan Chen,Charles D Smart,Fanny Laroumanie,Mingfang Ao,Liang Xiao,Anna Dikalova,Sergey Dikalov,Fernando Elijovich,Jason D. Foss,Natalia R. Barbaro,Justin P Van Beusecum,Serpil Muge Deger,Aseel Alsouqi,Hana A. Itani,Allison E. Norlander,Matthew R Alexander,Shilin Zhao,T. Alp Ikizler,Holly M. Scott Algood,Holly M. Scott Algood,Meena S. Madhur +22 more
TL;DR: It is shown in humans that peripheral blood T cell production of IL21 correlates with systolic BP and IL17A production, and data suggest that IL21 may be a novel therapeutic target for the treatment of hypertension and its micro- and macrovascular complications.