Clément Cochain

TL;DR: Single-cell RNA sequencing unprecedentedly uncovered the transcriptional landscape and phenotypic heterogeneity of aortic macrophages and monocyte-derived dendritic cells in atherosclerotic arteries and identified previously unrecognized macrophage populations and their gene expression signature, suggesting specialized functions.

TL;DR: The definition of leukocyte diversity by high-dimensional analyses enables a fine-grained analysis of aorticLeukocyte subsets, reveals new immunologic mechanisms and cell-type–specific pathways, and establishes a functional relevance for lesional leukocytes in human atherosclerosis.

TL;DR: Experimental unraveling of the mechanisms of angiogenesis, vessel maturation, and endothelial cell/cardiomyocyte cross talk in the ischemic heart, analysis of emerging pathways, and a better understanding of how cardiovascular risk factors impact endogenous and therapeutically stimulatedAngiogenesis would undoubtedly pave the way for the development of novel and hopefully efficient angiogenic targeting therapeutics for the treatment of acute MI.

TL;DR: A comprehensive meta-analysis of the diverse leukocyte infiltrate in atherosclerotic mouse aortas finds that monocytes, neutrophils, dendritic cells, natural killer cells, innate lymphoid cells-2, and CD (cluster of differentiation)-8 T cells form prominent and separate immune cell populations in atheosclerotic aorta.

TL;DR: MPs produced during tissue ischemia stimulate progenitor cell differentiation and subsequently promote postnatal neovascularization in mice with impaired vesiculation.