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Christoph J. Binder
Researcher at Medical University of Vienna
Publications - 275
Citations - 20668
Christoph J. Binder is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Medicine & Inflammation. The author has an hindex of 62, co-authored 230 publications receiving 16956 citations. Previous affiliations of Christoph J. Binder include Austrian Academy of Sciences & University of California, San Diego.
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Journal ArticleDOI
Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury
Yumiko Imai,Keiji Kuba,Keiji Kuba,G. Greg Neely,Rubina Yaghubian-Malhami,Thomas Perkmann,Geert van Loo,Maria A. Ermolaeva,Maria A. Ermolaeva,Ruud A. W. Veldhuizen,Y.H. Connie Leung,Hongliang Wang,Haolin Liu,Yang Sun,Manolis Pasparakis,Manolis Pasparakis,Manfred Kopf,Christin Mech,Sina Bavari,J. S. Malik Peiris,Arthur S. Slutsky,Shizuo Akira,Malin Hultqvist,Rikard Holmdahl,John M. Nicholls,Chengyu Jiang,Christoph J. Binder,Josef M. Penninger +27 more
TL;DR: It is reported that Toll-like receptor 4 (TLR4) mutant mice display natural resistance to acid-induced acute lung injury (ALI), and it is shown that TLR4-TRIF-TRAF6 signaling is a key disease pathway that controls the severity of ALI.
Journal ArticleDOI
Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase
Jannet T. Huang,John S. Welch,Mercedes Ricote,Christoph J. Binder,Timothy M. Willson,Carolyn J. Kelly,Joseph L. Witztum,Colin D. Funk,Douglas Conrad,Christopher K. Glass +9 more
TL;DR: Findings reveal a physiological role of 12/15-lipoxygenase in the generation of endogenous ligands for PPAR-γ, and suggest a paradigm for the regulation of nuclear receptor function by cytokines.
Journal ArticleDOI
Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL.
Christoph J. Binder,Sohvi Hörkkö,Sohvi Hörkkö,Asheesh Dewan,Mi-Kyung Chang,Emily P Kieu,Carl S. Goodyear,Peter X. Shaw,Wulf Palinski,Joseph L. Witztum,Gregg J. Silverman +10 more
TL;DR: Molecular mimicry between epitopes of oxLDL and S. pneumoniae is shown to indicate that these immune responses can have beneficial effects and indicate that in vivo exposure to pneumococci can affect atherogenesis.
Journal ArticleDOI
Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel
Jan Borén,M. John Chapman,M. John Chapman,Ronald M. Krauss,Chris J. Packard,Jacob F. Bentzon,Jacob F. Bentzon,Christoph J. Binder,Mat J.A.P. Daemen,Linda L. Demer,Robert A. Hegele,Stephen J. Nicholls,Børge G. Nordestgaard,Gerald F. Watts,Gerald F. Watts,Eric Bruckert,Sergio Fazio,Brian A. Ference,Brian A. Ference,Ian D. Graham,Jay D. Horton,Ulf Landmesser,Ulrich Laufs,Luis Masana,Gerard Pasterkamp,Frederick J. Raal,Kausik K. Ray,Heribert Schunkert,Marja-Riitta Taskinen,Bart van de Sluis,Olov Wiklund,Lale Tokgozoglu,Alberico L. Catapano,Henry N. Ginsberg +33 more
TL;DR: In this paper, the authors proposed a method to solve the problem of the problem: this paper ] of "uniformity" of the distribution of data points in the data set.
Journal ArticleDOI
Innate and acquired immunity in atherogenesis.
Christoph J. Binder,Mi-Kyung Chang,Peter X. Shaw,Yury I. Miller,Karsten Hartvigsen,Asheesh Dewan,Joseph L. Witztum +6 more
TL;DR: Traditional risk factors like hypercholesterolemia are important for atherogenesis, but it is now apparent that the immune system also plays an important role and this could lead to novel therapeutic approaches that involve immune modulation.