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Akula Bala Pramod
Researcher at La Jolla Institute for Allergy and Immunology
Publications - 25
Citations - 2034
Akula Bala Pramod is an academic researcher from La Jolla Institute for Allergy and Immunology. The author has contributed to research in topics: Pharmacophore & Virtual screening. The author has an hindex of 14, co-authored 25 publications receiving 1174 citations. Previous affiliations of Akula Bala Pramod include University of North Dakota & Indian Veterinary Research Institute.
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Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively Activated Macrophages.
TL;DR: This fundamental discrepancy explains why most surface markers identified on in vitro generated macrophages do not translate to the in vivo situation and is justified by comparing the gene lists positively or negatively correlated with the ratio of IL-12 and arginase 1 in transcriptomes of LPS-treated peritoneal macrophades.
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Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry
Holger Winkels,Erik Ehinger,Melanie Vassallo,Konrad Buscher,Huy Q. Dinh,Kouji Kobiyama,Anouk A.J. Hamers,Clément Cochain,Ehsan Vafadarnejad,Antoine-Emmanuel Saliba,Alma Zernecke,Akula Bala Pramod,Amlan K. Ghosh,Nathaly Anto Michel,Natalie Hoppe,Ingo Hilgendorf,Andreas Zirlik,Catherine C. Hedrick,Klaus Ley,Klaus Ley,Dennis Wolf +20 more
TL;DR: The definition of leukocyte diversity by high-dimensional analyses enables a fine-grained analysis of aorticLeukocyte subsets, reveals new immunologic mechanisms and cell-type–specific pathways, and establishes a functional relevance for lesional leukocytes in human atherosclerosis.
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SLC6 transporters: structure, function, regulation, disease association and therapeutics.
TL;DR: The SLC6 family of secondary active transporters are integral membrane solute carrier proteins characterized by the Na(+)-dependent translocation of small amino acid or amino acid-like substrates that are associated with a number of human diseases and disorders making this family a critical target for therapeutic development.
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Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival.
Konrad Buscher,Erik Ehinger,Pritha P. Gupta,Akula Bala Pramod,Dennis Wolf,George Tweet,Calvin Pan,Charles D. Mills,Aldons J. Lusis,Klaus Ley +9 more
TL;DR: This study highlights natural activation diversity as a disease-relevant dimension in macrophage biology, and suggests the HMDP as a viable tool to increase translatability of mouse data to clinical settings.
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How Mouse Macrophages Sense What Is Going On
TL;DR: Almost 200 key macrophage receptors that help the macrophages sense what is going on are reviewed, including pathogen-derived molecules, the state of the surrounding tissue cells, apoptotic and necrotic cell death, antibodies and immune complexes, altered self molecules, extracellular matrix components, and cytokines, including chemokines.