A
Alvaro Garcia
Researcher at University of Technology, Sydney
Publications - 56
Citations - 1372
Alvaro Garcia is an academic researcher from University of Technology, Sydney. The author has contributed to research in topics: Na+/K+-ATPase & Lipid bilayer. The author has an hindex of 19, co-authored 55 publications receiving 1188 citations. Previous affiliations of Alvaro Garcia include University of Sydney & Royal North Shore Hospital.
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Journal ArticleDOI
Reversible Oxidative Modification A Key Mechanism of Na+-K+ Pump Regulation
Gemma A. Figtree,Chia-Chi Liu,Stéphanie Bibert,Elisha J. Hamilton,Alvaro Garcia,Caroline N. White,Karin K.M. Chia,Flemming Cornelius,Kaethi Geering,Helge H. Rasmussen +9 more
TL;DR: It is proposed that kinase-dependent regulation of the Na+-K+ pump occurs via glutathionylation of its β1 subunit at Cys46, which has implications for pathophysiological conditions characterized by neurohormonal dysregulation, myocardial oxidative stress and raised myocyte Na+ levels.
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Complete Sertoli cell proliferation induced by follicle-stimulating hormone (FSH) independently of luteinizing hormone activity: evidence from genetic models of isolated FSH action.
Charles M. Allan,Alvaro Garcia,Jenny Spaliviero,Fu-Ping Zhang,Mark Jimenez,Ilpo Huhtaniemi,David J. Handelsman +6 more
TL;DR: It is revealed that full Sertoli cell proliferation can be accomplished by FSH activity without LH requirement, and although postnatal mitotic and meiotic germ cell development can be promoted by Fsh alone, LH-mediated effects remain a critical determinant for initiating the full complement of germ cells and final stages of postmeiotic development.
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β3 Adrenergic Stimulation of the Cardiac Na+-K+ Pump by Reversal of an Inhibitory Oxidative Modification
Henning Bundgaard,Chia-Chi Liu,Alvaro Garcia,Elisha J. Hamilton,Yifei Huang,Karin K.M. Chia,Stephen N. Hunyor,Gemma A. Figtree,Helge H. Rasmussen +8 more
TL;DR: The in vivo effect of BRL37344 on contractility of the nonfailing and failing heart in sheep was consistent with a beneficial effect of Na+-K+ pump stimulation in heart failure, indicating a beneficial mechanism that facilitates the export of excess Na+.
Journal ArticleDOI
FXYD Proteins Reverse Inhibition of the Na+-K+ Pump Mediated by Glutathionylation of Its β1 Subunit
Stéphanie Bibert,Chia-Chi Liu,Gemma A. Figtree,Gemma A. Figtree,Alvaro Garcia,Alvaro Garcia,Elisha J. Hamilton,Francesca M. Marassi,Kathleen J. Sweadner,Flemming Cornelius,Käthi Geering,Helge H. Rasmussen,Helge H. Rasmussen +12 more
TL;DR: By facilitating deglutathionylation of the β1 subunit, FXYD proteins reverse oxidative inhibition of the Na+-K+ pump and play a dynamic role in its regulation.
Journal ArticleDOI
Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidase.
Caroline N. White,Gemma A. Figtree,Chia-Chi Liu,Alvaro Garcia,Elisha J. Hamilton,Karin K.M. Chia,Helge H. Rasmussen +6 more
TL;DR: It is concluded that Angiotensin II inhibits the Na(+)-K(+) pump via PKC-dependent NADPH oxidase activation.