Alvin Farrel

TL;DR: Genomically characterize 261 PDX models from 37 unique pediatric cancers; demonstrate faithful recapitulation of histologies and subtypes; refine the understanding of relapsed disease; and use expression signatures to classify tumors for TP53 and NF1 pathway inactivation.

TL;DR: In this article, a peptide-centric chimeric antigen receptor (CAR) was proposed to target unmutated peptide QYNPIRTTF, discovered on HLA-A*24:02, derived from the neuroblastoma dependency gene and master transcriptional regulator PHOX2B.

TL;DR: A SARS-CoV-2 vaccine design concept based on identification of highly conserved regions of the viral genome and newly acquired adaptations, both predicted to generate epitopes presented on MHC class I and II across the vast majority of the population is proposed.

TL;DR: Findings underscore the importance of YAP activity in response to trametinib in RAS-driven neuroblastomas, as well as the potential for targeting YAP in a trametInib combination, and the need for targeting the Hippo pathway transcriptional coactivator protein YAP1 in such a combination.

TL;DR: It is found that radiation and tumor-specific immunocytokine generate an in situ vaccination response in syngeneic mice bearing large tumors in a mouse melanoma model, suggesting that a combined innate and adaptive immunotherapeutic approach can be effective against immunologically cold syngenesic murine neuroblastoma.