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Kristopher R. Bosse
Researcher at Children's Hospital of Philadelphia
Publications - 34
Citations - 2160
Kristopher R. Bosse is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Neuroblastoma & Genome-wide association study. The author has an hindex of 12, co-authored 29 publications receiving 1722 citations. Previous affiliations of Kristopher R. Bosse include Children's Hospital Los Angeles & University of Pennsylvania.
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Journal ArticleDOI
Copy number variation at 1q21.1 associated with neuroblastoma
Sharon J. Diskin,Cuiping Hou,Joseph T. Glessner,Edward F. Attiyeh,Edward F. Attiyeh,Marci Laudenslager,Kristopher R. Bosse,Kristina A. Cole,Yael P. Mosse,Yael P. Mosse,Andrew Wood,Jill E. Lynch,Katlyn Pecor,Maura Diamond,Cynthia Winter,Kai Wang,Cecilia Kim,Elizabeth A. Geiger,Patrick McGrady,Alexandra I. F. Blakemore,Wendy B. London,Tamim H. Shaikh,Tamim H. Shaikh,Jonathan P. Bradfield,Struan F.A. Grant,Struan F.A. Grant,Hongzhe Li,Marcella Devoto,E. Rappaport,E. Rappaport,Hakon Hakonarson,Hakon Hakonarson,John M. Maris,John M. Maris +33 more
TL;DR: The identification of a common CNV at chromosome 1q21.1 associated with neuroblastoma in the discovery set is described and a previously unknown transcript within the CNV that showed high sequence similarity to several neuro Blastoma breakpoint family genes and represents a new member of this gene family (NBPF23).
Journal ArticleDOI
The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution
Orit Rozenblatt-Rosen,Aviv Regev,Aviv Regev,Aviv Regev,Philipp Oberdoerffer,Tal Nawy,Anna Hupalowska,Jennifer Rood,Orr Ashenberg,Ethan Cerami,Robert J. Coffey,Emek Demir,Li Ding,Edward D. Esplin,James M. Ford,Jeremy Goecks,Sharmistha Ghosh,Joe W. Gray,Justin Guinney,Justin Guinney,Sean E. Hanlon,Shannon K. Hughes,E. Shelley Hwang,Christine A. Iacobuzio-Donahue,Judit Jané-Valbuena,Bruce E. Johnson,Ken S. Lau,Tracy Lively,Sarah A. Mazzilli,Dana Pe'er,Sandro Santagata,Sandro Santagata,Alex K. Shalek,Denis Schapiro,Denis Schapiro,Michael Snyder,Peter K. Sorger,Avrum E. Spira,Avrum E. Spira,Sudhir Srivastava,Kai Tan,Kai Tan,Robert West,Elizabeth H. Williams,Elizabeth H. Williams,Denise Aberle,Samuel Achilefu,Foluso O. Ademuyiwa,Andrew Adey,Rebecca Aft,Rachana Agarwal,Ruben A. Aguilar,Fatemeh Alikarami,Viola Allaj,Christopher I. Amos,Robert A. Anders,Michael R. Angelo,Kristen Anton,Jon C. Aster,Özgün Babur,Amir Bahmani,Akshay Balsubramani,David M. Barrett,Jennifer Beane,Diane Bender,Kathrin M. Bernt,Lynne D. Berry,Courtney Betts,Julie Bletz,Katie Blise,Adrienne Boire,Genevieve M. Boland,Alexander D. Borowsky,Kristopher R. Bosse,Matthew J. Bott,Edward S. Boyden,James D. Brooks,Raphael Bueno,Erik A. Burlingame,Qiuyin Cai,Joshua D. Campbell,Wagma Caravan,Hassan Chaib,Joseph M. Chan,Young Hwan Chang,Deyali Chatterjee,Ojasvi Chaudhary,Alyce A. Chen,Bob Chen,Changya Chen,Chia hui Chen,Feng Chen,Yuan Chen,Milan G. Chheda,Koei Chin,Roxanne Chiu,Shih Kai Chu,Rodrigo Chuaqui,Jaeyoung Chun,Luis Cisneros,Graham A. Colditz,Kristina A. Cole,Natalie B. Collins,Kévin Contrepois,Lisa M. Coussens,Allison L. Creason,Daniel J. Crichton,Christina Curtis,Tanja M. Davidsen,Sherri R. Davies,Ino de Bruijn,Laura DelloStritto,Angelo M. De Marzo,David G. DeNardo,Dinh Diep,Sharon J. Diskin,Xengie Doan,Julia L. Drewes,Stephen Dubinett,Michael A. Dyer,Jacklynn V. Egger,Jennifer Eng,Barbara E. Engelhardt,Graham Erwin,Laura J. Esserman,Alex Felmeister,Heidi S. Feiler,Ryan C. Fields,Stephen A. Fisher,Keith T. Flaherty,Jennifer Flournoy,Angelo Fortunato,Allison Frangieh,Jennifer L. Frye,Robert S. Fulton,Danielle Galipeau,Siting Gan,Jianjiong Gao,Long Gao,Peng Gao,Vianne R. Gao,Tim Geiger,Ajit George,Gad Getz,Marios Giannakis,David L Gibbs,William E. Gillanders,Simon P. Goedegebuure,Alanna Gould,Kate H.C. Gowers,William J. Greenleaf,Jeremy Gresham,Jennifer L. Guerriero,Tuhin Kumar Guha,Alexander R. Guimaraes,David A. Gutman,Nir Hacohen,Sean E. Hanlon,Casey R. Hansen,Olivier Harismendy,Kathleen A. Harris,Aaron N. Hata,Akimasa Hayashi,Cody N. Heiser,Karla Helvie,John M. Herndon,Gilliam Hirst,Frank Hodi,Travis J. Hollmann,Aaron M. Horning,James J. Hsieh,Shannon Hughes,Won Jae Huh,Stephen P. Hunger,Shelley Hwang,Heba Ijaz,Benjamin Izar,Connor A. Jacobson,Sam M. Janes,Reyka G Jayasinghe,Lihua Jiang,Brett Johnson,Bruce E. Johnson,Tao Ju,Humam Kadara,Klaus H. Kaestner,Jacob Kagan,Lukas Kalinke,Robert L. Keith,Aziz Khan,Warren A. Kibbe,Albert H. Kim,Erika Kim,Junhyong Kim,Annette Kolodzie,Mateusz Kopytra,Eran Kotler,Robert Krueger,Kostyantyn Krysan,Anshul Kundaje,Uri Ladabaum,Blue B. Lake,Huy Lam,Rozelle Laquindanum,Ashley M. Laughney,Hayan Lee,Marc E. Lenburg,Carina A. Leonard,Ignaty Leshchiner,Rochelle Levy,Jerry Li,Christine G. Lian,Kian-Huat Lim,Jia-Ren Lin,Yiyun Lin,Qi Liu,Ruiyang Liu,William J.R. Longabaugh,Teri A. Longacre,Cynthia X. Ma,Mary Catherine Macedonia,Tyler Madison,Christopher G. Maher,Anirban Maitra,Netta Makinen,Danika Makowski,Carlo C. Maley,Zoltan Maliga,Diego Mallo,John M. Maris,Nick Markham,Jeffrey R. Marks,Daniel Martinez,Robert J. Mashl,Ignas Masilionais,Jennifer Mason,Joan Massagué,Pierre P. Massion,Marissa Mattar,Richard Mazurchuk,Linas Mazutis,Eliot T. McKinley,Joshua F. McMichael,Daniel T. Merrick,Matthew Meyerson,Julia R. Miessner,Gordon B. Mills,Meredith A. Mills,Suman B. Mondal,Motomi Mori,Yuriko Mori,Elizabeth Moses,Yael P. Mosse,Jeremy L. Muhlich,George F. Murphy,Nicholas Navin,Michel Nederlof,Reid M. Ness,Stephanie A. Nevins,Milen Nikolov,Ajit J. Nirmal,Garry P. Nolan,Edward Novikov,Brendan O'Connell,Michael Offin,Stephen T. Oh,Anastasiya Olson,Alex Ooms,Miguel Ossandon,Kouros Owzar,Swapnil Parmar,Tasleema Patel,Gary J. Patti,Itsik Pe'er,Tao Peng,Daniel Persson,Marvin Petty,Hanspeter Pfister,Kornelia Polyak,Kamyar Esmaeili Pourfarhangi,Sidharth V. Puram,Qi Qiu,Álvaro Quintanal-Villalonga,Arjun Raj,Marisol A. Ramirez-Solano,Rumana Rashid,Ashley N. Reeb,Mary E. Reid,Adam C. Resnick,Sheila Reynolds,Jessica L. Riesterer,Scott J. Rodig,Joseph T. Roland,Sonia Rosenfield,Asaf Rotem,Sudipta Roy,Charles M. Rudin,Marc D. Ryser,Maria Santi-Vicini,Kazuhito Sato,Deborah Schrag,Nikolaus Schultz,Cynthia L. Sears,Rosalie C. Sears,Subrata Sen,Triparna Sen,Alex K. Shalek,Jeff Sheng,Quanhu Sheng,Kooresh I. Shoghi,Martha J. Shrubsole,Yu Shyr,Alexander B. Sibley,Kiara Siex,Alan J. Simmons,Dinah S. Singer,Shamilene Sivagnanam,Michal Slyper,Artem Sokolov,Sheng-Kwei Song,Austin N. Southard-Smith,Avrum Spira,Janet Stein,Phillip B. Storm,Elizabeth H. Stover,Siri H. Strand,Timothy Su,Damir Sudar,Ryan P. Sullivan,Lea F. Surrey,Mario L. Suvà,Nadezhda V. Terekhanova,Luke Ternes,Lisa Thammavong,Guillaume Thibault,George Thomas,Vesteinn Thorsson,Ellen Todres,Linh M. Tran,Madison Tyler,Yasin Uzun,Anil Vachani,Eliezer M. Van Allen,Simon N. Vandekar,Deborah J. Veis,Sébastien Vigneau,Arastoo Vossough,Angela J. Waanders,Nikhil Wagle,Liang-Bo Wang,Michael C. Wendl,Robert B. West,Chi yun Wu,Hao Wu,Hung Yi Wu,Matthew A. Wyczalkowski,Yubin Xie,Xiaolu Yang,Clarence Yapp,Wenbao Yu,Yinyin Yuan,Dadong Zhang,Kun Zhang,Mianlei Zhang,Nan Zhang,Yantian Zhang,Yanyan Zhao,Daniel Cui Zhou,Zilu Zhou,Houxiang Zhu,Qin Zhu,Xiangzhu Zhu,Yuankun Zhu,Xiaowei Zhuang +373 more
TL;DR: The Human Tumor Atlas Network (HTAN), part of the NCI Cancer Moonshot Initiative, will establish a clinical, experimental, computational, and organizational framework to generate informative and accessible three-dimensional atlases of cancer transitions for a diverse set of tumor types.
Journal ArticleDOI
Integrative genomics identifies LMO1 as a neuroblastoma oncogene
Kai Wang,Kai Wang,Sharon J. Diskin,Haitao Zhang,Edward F. Attiyeh,Cynthia Winter,Cuiping Hou,Robert W. Schnepp,Maura Diamond,Kristopher R. Bosse,Patrick A. Mayes,Joseph T. Glessner,Cecilia Kim,Edward C. Frackelton,Maria Garris,Qun Wang,Wendy Glaberson,Rosetta M. Chiavacci,Le Nguyen,Le Nguyen,Jayanti Jagannathan,Norihisa Saeki,Hiroki Sasaki,Struan F.A. Grant,Struan F.A. Grant,Achille Iolascon,Yael P. Mosse,Yael P. Mosse,Kristina A. Cole,Kristina A. Cole,Hongzhe Li,Marcella Devoto,Patrick McGrady,Wendy B. London,Mario Capasso,Nazneen Rahman,Hakon Hakonarson,Hakon Hakonarson,John M. Maris,John M. Maris +39 more
TL;DR: Data show that common polymorphisms at the LMO1 locus are strongly associated with susceptibility to developing neuroblastoma, but also may influence the likelihood of further somatic alterations at this locus, leading to malignant progression.
Journal ArticleDOI
Common variations in BARD1 influence susceptibility to high-risk neuroblastoma
Mario Capasso,Marcella Devoto,Cuiping Hou,Shahab Asgharzadeh,Joseph T. Glessner,Edward F. Attiyeh,Edward F. Attiyeh,Yael P. Mosse,Yael P. Mosse,Cecilia Kim,Sharon J. Diskin,Sharon J. Diskin,Kristina A. Cole,Kristina A. Cole,Kristopher R. Bosse,Kristopher R. Bosse,Maura Diamond,Maura Diamond,Marci Laudenslager,Marci Laudenslager,Cynthia Winter,Cynthia Winter,Jonathan P. Bradfield,Richard H Scott,Jayanti Jagannathan,Maria Garris,Carmel McConville,Wendy B. London,Robert C. Seeger,Struan F.A. Grant,Struan F.A. Grant,Hongzhe Li,Nazneen Rahman,Eric F. Rappaport,Eric F. Rappaport,Hakon Hakonarson,Hakon Hakonarson,John M. Maris,John M. Maris +38 more
TL;DR: In this paper, the authors conducted a genome-wide association study (GWAS) focused on the high-risk subset of neuroblastoma and found significant association with known BARD1 nonsynonymous SNPs.
Journal ArticleDOI
RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma
Kristina A. Cole,Jonathan Huggins,Michael P. LaQuaglia,Chase Hulderman,Mike R. Russell,Kristopher R. Bosse,Sharon J. Diskin,Edward F. Attiyeh,Rachel Sennett,Geoffrey T. Norris,Marci Laudenslager,Andrew C. Wood,Patrick A. Mayes,Jayanti Jagannathan,Cynthia Winter,Yael P. Mosse,John M. Maris +16 more
TL;DR: The power of a functional RNAi screen to identify tractable therapeutical targets in neuroblastoma and support CHK1 inhibition strategies in this disease are shown.