Amanda Forbes

TL;DR: It has been postulated that, given its chemical properties, PCN is able to readily cross biological membranes, however studies have yet to be undertaken to evaluate this effect, and this review highlights the possible manifestations of PCN exposure.

TL;DR: In vivo data was consistent with in vitro findings as the quinazoline based α-antagonists prevented angiogenesis and decreased tumour mass in mice models of PCa, and retrospective studies show a decreased incidence ofPCa in males exposed to α-Antagonists.

TL;DR: The aim of these studies was to assess the relative cytotoxic potencies of α1‐adrenoceptor antagonists and the mechanisms involved in these actions.

TL;DR: It is shown here that modulation of autophagy may influence docetaxel-induced toxicity in prostate cancer cells and these effects may differ between cell lines.

TL;DR: Investigation of the role of redox-sensitive MAPK in PCN-induced toxicity in A549 cells shows that PCN rapidly increased ERK1/2 phosphorylation after 5min, and confirms that oxidative stress contributes to PCNs toxicity, but suggests the contribution of oxidative stress is independent of ERK 1/2 signaling.