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Amanda J. Stranks
Researcher at Boston Children's Hospital
Publications - 16
Citations - 1663
Amanda J. Stranks is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Autophagy & Immunoglobulin E. The author has an hindex of 12, co-authored 16 publications receiving 1383 citations. Previous affiliations of Amanda J. Stranks include Wellcome Trust Centre for Human Genetics & Harvard University.
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Journal ArticleDOI
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance
Monika Mortensen,Elizabeth J. Soilleux,Gordana Djordjevic,Rebecca Tripp,Michael Lutteropp,Elham Sadighi-Akha,Amanda J. Stranks,Julie Glanville,Samantha J. L. Knight,Sten Eirik W. Jacobsen,Kamil R. Kranc,Anna Katharina Simon +11 more
TL;DR: Adult mouse LSK cells unable to undergo autophagy contain fewer HSCs, accumulate mitochondria, and fail to reconstitute lethally irradiated mice.
Journal ArticleDOI
Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation
Thomas Riffelmacher,Thomas Riffelmacher,Alexander J. Clarke,Felix Richter,Amanda J. Stranks,Sumeet Pandey,S Danielli,Philip Hublitz,Zhanru Yu,Errin Johnson,Tobias Schwerd,James S. O. McCullagh,Holm H. Uhlig,Sten Eirik W. Jacobsen,Anna Katharina Simon,Anna Katharina Simon +15 more
TL;DR: It is shown that autophagy-mediated lipolysis provides free fatty acids to support a mitochondrial respiration pathway essential to neutrophil differentiation.
Journal ArticleDOI
Autophagy is activated in systemic lupus erythematosus and required for plasmablast development.
Alexander J. Clarke,Ursula Ellinghaus,Andrea Cortini,Amanda J. Stranks,Anna Katharina Simon,Marina Botto,Timothy J. Vyse +6 more
TL;DR: In this paper, the role of autophagy in the pathogenesis of human and murine lupus, a disease in which B cells are critical effectors of pathology, was explored.
Journal ArticleDOI
Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia.
Alexander Scarth Watson,Thomas Riffelmacher,Amanda J. Stranks,Owen Williams,J de Boer,K Cain,M MacFarlane,Joanna F. McGouran,Benedikt M. Kessler,Shivani Khandwala,O Chowdhury,Daniel J. Puleston,Kanchan Phadwal,Monika Mortensen,David J. P. Ferguson,Elizabeth J. Soilleux,Petter S. Woll,Sew Jacobsen,Anna Katharina Simon +18 more
TL;DR: It is demonstrated that loss of Atg5 results in an identical HSPC phenotype as loss ofAtg7, confirming a general role for autophagy in HSPCs regulation and pointing to low autophagic flux, providing a general advantage for tumor growth.
Journal ArticleDOI
Autophagy Controls Acquisition of Aging Features in Macrophages
Amanda J. Stranks,Anne Louise Hansen,Isabel Panse,Monika Mortensen,David J. P. Ferguson,Daniel J. Puleston,Kevin Shenderov,Alexander Scarth Watson,Marc Veldhoen,Kanchan Phadwal,Vincenzo Cerundolo,Anna Katharina Simon +11 more
TL;DR: For the first time, autophagy modulation may prevent excess inflammation and preserve macrophage function during aging, improving immune responses and reducing the morbidity and mortality associated with inflamm-aging.