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Amanda L. Marzo
Researcher at Rush University Medical Center
Publications - 51
Citations - 6127
Amanda L. Marzo is an academic researcher from Rush University Medical Center. The author has contributed to research in topics: Cytotoxic T cell & CD8. The author has an hindex of 28, co-authored 47 publications receiving 5815 citations. Previous affiliations of Amanda L. Marzo include University of Connecticut & Edward Jenner Institute for Vaccine Research.
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Journal ArticleDOI
Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
TL;DR: In response to viral or bacterial infection, antigen-specific CD8 T cells migrated to nonlymphoid tissues and were present as long-lived memory cells, pointing to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection.
Journal ArticleDOI
Initial T cell frequency dictates memory CD8+ T cell lineage commitment.
Amanda L. Marzo,Kimberly D. Klonowski,Agnes Le Bon,Persephone Borrow,David F. Tough,Leo Lefrançois +5 more
TL;DR: It is shown here that naive T cell precursor frequency profoundly influenced the pathway along which CD8+ memory T cells developed and provide a means for identifying factors controlling memory T cell lineage commitment.
Journal ArticleDOI
Induction of Tumor Cell Apoptosis In Vivo Increases Tumor Antigen Cross-Presentation, Cross-Priming Rather than Cross-Tolerizing Host Tumor-Specific CD8 T Cells
Anna K. Nowak,Richard A. Lake,Amanda L. Marzo,Amanda L. Marzo,Bernadette Scott,Bernadette Scott,William R. Heath,Edward J. Collins,Jeffrey A. Frelinger,Bruce W. S. Robinson +9 more
TL;DR: T tumor cell apoptosis in vivo neither sequesters tumor Ags nor cross-tolerizes tumor-specific CD8 cells, which has fundamental consequences for the development of tumor immunotherapy protocols and for understanding T cell reactivity to tumors and the in vivo immune responses to apoptotic cells.
Journal ArticleDOI
Organ-specific regulation of the CD8 T cell response to Listeria monocytogenes infection.
Constance D. Pope,Sung-Kwon Kim,Amanda L. Marzo,Kristina Williams,Jiu Jiang,Hao Shen,Leo Lefrançois +6 more
TL;DR: The results point to novel pathways of tissue-specific regulation of primary and memory antimicrobial CD8 T cell responses that are dependent on infectious dose and inversely correlated with the magnitude of the recall response after oral challenge.
Journal ArticleDOI
Dynamics of Blood-Borne CD8 Memory T Cell Migration In Vivo
Kimberly D. Klonowski,Kristina Williams,Amanda L. Marzo,David A. Blair,Elizabeth G. Lingenheld,Leo Lefrançois +5 more
TL;DR: The blood-borne T cell pool serves to maintain the homeostasis of tissue-based memory populations using adoptive transfer and parabiosis systems to examine the ability of circulating microbe-specific memory T cells to populate lymphoid and nonlymphoid tissues.