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Ambreena Siddiq
Researcher at Cornell University
Publications - 13
Citations - 1337
Ambreena Siddiq is an academic researcher from Cornell University. The author has contributed to research in topics: Neuroprotection & Hypoxia-inducible factors. The author has an hindex of 13, co-authored 13 publications receiving 1267 citations. Previous affiliations of Ambreena Siddiq include Harvard University & Burke Rehabilitation Hospital.
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Journal ArticleDOI
HDAC6 is a target for protection and regeneration following injury in the nervous system
Mark A. Rivieccio,Camille Brochier,Dianna E. Willis,Breset A. Walker,Melissa A. D'Annibale,Kathryn McLaughlin,Ambreena Siddiq,Alan P. Kozikowski,Samie R. Jaffrey,Jeffery L. Twiss,Rajiv R. Ratan,Brett Langley +11 more
TL;DR: It is shown that pan-HDAC inhibition not only promotes neuronal protection against oxidative stress, a common mediator of injury in many neurological conditions, but also promotes neurite growth on myelin-associated glycoprotein and chondroitin sulfate proteoglycan substrates.
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Hypoxia-inducible factor prolyl 4-hydroxylase inhibition: A target for neuroprotection in the central nervous system
Ambreena Siddiq,Ambreena Siddiq,Issam A. Ayoub,Juan C. Chavez,Juan C. Chavez,Leila Aminova,Sapan Shah,Joseph C. LaManna,Stephanie M. Patton,James R. Connor,Robert A. Cherny,Irene Volitakis,Ashley I. Bush,Ashley I. Bush,Ingrid Langsetmo,Todd W. Seeley,Volkmar Günzler,Rajiv R. Ratan,Rajiv R. Ratan +18 more
TL;DR: Low molecular weight and peptide HIF prolyl 4-hydroxylase inhibitors are identified as novel neurological therapeutics for stroke as well as other diseases associated with oxidative stress.
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Selective Inhibition of Hypoxia-Inducible Factor (HIF) Prolyl-Hydroxylase 1 Mediates Neuroprotection against Normoxic Oxidative Death via HIF- and CREB-Independent Pathways
Ambreena Siddiq,Leila R. Aminova,Carol M. Troy,Kyungsun Suh,Zachary R. Messer,Gregg L. Semenza,Rajiv R. Ratan +6 more
TL;DR: Together, these studies suggest that iron chelators can prevent normoxic oxidative neuronal death through selective inhibition of PHD1 but independent of HIF-1α and CREB; and that Hif-2α, not HIF -PHD, regulates susceptibility to normoxic antioxidant neuronal death.
Journal ArticleDOI
Hypoxia inducible factor prolyl 4-hydroxylase enzymes: center stage in the battle against hypoxia, metabolic compromise and oxidative stress.
TL;DR: The possible role of PHDs in regulation of both HIF-dependent and -independent cell survival pathways in the nervous system with particular attention to the co-substrate requirements for these enzymes is discussed.
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Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease.
Donna W. Lee,Subramanian Rajagopalan,Ambreena Siddiq,Roberto Gwiazda,Lichuan Yang,M. Flint Beal,Rajiv R. Ratan,Julie K. Andersen +7 more
TL;DR: Novel data is provided extending the possible therapeutic utility of HIF induction to a Parkinson disease model of neurodegeneration, which may prove beneficial not only in this disorder itself but also in other diseases associated with metal-induced oxidative stress.