R
Rajiv R. Ratan
Researcher at Cornell University
Publications - 211
Citations - 16872
Rajiv R. Ratan is an academic researcher from Cornell University. The author has contributed to research in topics: Neuroprotection & Oxidative stress. The author has an hindex of 70, co-authored 200 publications receiving 14942 citations. Previous affiliations of Rajiv R. Ratan include New York University & Burke Rehabilitation Hospital.
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Journal ArticleDOI
Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway
Seija Lehnardt,Leon J. Massillon,Pamela L. Follett,Frances E. Jensen,Rajiv R. Ratan,Paul A. Rosenberg,Joseph J. Volpe,Timothy Vartanian +7 more
TL;DR: A mechanistic link among innate immunity, TLRs, and neurodegeneration is demonstrated and microglia is identified as the major lipopolysaccharide-responsive cell in the CNS.
Journal ArticleDOI
Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice
Robert J. Ferrante,James K. Kubilus,Junghee Lee,Hoon Ryu,Ayshe Ana Beesen,Birgit Zucker,Karen L. Smith,Neil W. Kowall,Rajiv R. Ratan,Ruth Luthi-Carter,Steven M. Hersch +10 more
TL;DR: Findings strengthen the hypothesis that transcriptional dysfunction plays a role in the pathogenesis of HD and suggest that therapies aimed at modulating transcription may target early pathological events and provide clinical benefits to HD patients.
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Oxidative stress induces apoptosis in embryonic cortical neurons.
TL;DR: It is found that glutathione depletion leads to hypercondensation and fragmentation of chromatin into spherical or irregular shapes, a morphologic signature of apoptosis, which suggests that oxidative stress can induce apoptosis in neurons.
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Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke.
Ishraq Alim,Joseph T. Caulfield,Yingxin Chen,Vivek Swarup,Vivek Swarup,Daniel H. Geschwind,Elena Ivanova,Javier Seravalli,Youxi Ai,Lauren H Sansing,Emma J. Ste.Marie,Robert J. Hondal,Sushmita Mukherjee,John W. Cave,Botir T. Sagdullaev,Saravanan S. Karuppagounder,Rajiv R. Ratan +16 more
TL;DR: Systemic administration of a brain-penetrant selenopeptide activates homeostatic transcription to inhibit cell death and improves function when delivered after hemorrhagic or ischemic stroke.
Journal ArticleDOI
Neuroprotective Effects of Phenylbutyrate in the N171-82Q Transgenic Mouse Model of Huntington's Disease
Gabriella Gárdián,Susan E. Browne,Dong-Kug Choi,Péter Klivényi,Jason Gregorio,James K. Kubilus,James K. Kubilus,Hoon Ryu,Hoon Ryu,Brett Langley,Rajiv R. Ratan,Rajiv R. Ratan,Robert J. Ferrante,Robert J. Ferrante,M. Flint Beal +14 more
TL;DR: Results show that administration of phenylbutyrate, at doses that are well tolerated in man, exerts significant neuroprotective effects in a transgenic mouse model of HD, and therefore represents a very promising therapeutic approach for HD.