Amelia F. Alessi

TL;DR: G body formation is a conserved, adaptive response to increase glycolytic output during hypoxia or tumorigenesis, and it is suggested that G bodies form in human hepatocarcinoma cells inhypoxia.

TL;DR: The worm HEN1 ortholog, HENN-1 (HEN of Nematode), is required for methylation of piRNAs and some endogenous and exogenous small interfering RNAs, and these findings support a model wherein methylation status of a metazoan small RNA is dictated by the Argonaute to which it binds.

TL;DR: F fused in sarcoma (FUS), an RNA-binding protein linked to neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), interacts with the core miRISC component AGO2 and is required for optimal microRNA-mediated gene silencing.

TL;DR: N nanopore-based direct RNA sequencing is applied to characterize the developmental polyadenylated transcriptome of C. elegans, providing support for 23,865 splice isoforms across 14,611 genes, without the need for computational reconstruction of gene models and determining that poly(A) tail lengths of transcripts vary across development, as do the strengths of previously reported correlations between poly( A) tail length and expression level.

TL;DR: N nanopore-based direct RNA sequencing is applied to characterize the developmental polyadenylated transcriptome of C. elegans, providing support for 20,902 splice isoforms across 14,115 genes, without the need for computational reconstruction of gene models and determining that poly(A) tail lengths of transcripts vary across development, as do the strengths of previously reported correlations between poly( A) tail length and expression level.