H
Hong-he Liu
Researcher at Johns Hopkins University
Publications - 11
Citations - 408
Hong-he Liu is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: DNA & DNA supercoil. The author has an hindex of 9, co-authored 9 publications receiving 275 citations. Previous affiliations of Hong-he Liu include Johns Hopkins University School of Medicine & Chinese Academy of Sciences.
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Journal ArticleDOI
Guanine-vacancy–bearing G-quadruplexes responsive to guanine derivatives
TL;DR: A unique type of G-quadruplex that contains a G-vacancy and is stabilized by guanine derivatives and is able to manipulate the tracking activity of protein on DNA as exemplified by a DNA polymerase-catalyzed DNA synthesis is found.
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FUS Regulates Activity of MicroRNA-Mediated Gene Silencing
Tao Zhang,Yen Ching Wu,Patrick C. Mullane,Yon Ju Ji,Hong-he Liu,Lu He,Amit Arora,Ho Yon Hwang,Amelia F. Alessi,Amirhossein Ghanbari Niaki,Goran Periz,Lin Guo,Hejia Wang,Elad Elkayam,Leemor Joshua-Tor,Sua Myong,John Kim,James Shorter,Shao En Ong,Anthony K.L. Leung,Jiou Wang +20 more
TL;DR: F fused in sarcoma (FUS), an RNA-binding protein linked to neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), interacts with the core miRISC component AGO2 and is required for optimal microRNA-mediated gene silencing.
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DNA G-quadruplex formation in response to remote downstream transcription activity: long-range sensing and signal transducing in DNA double helix
TL;DR: It is shown that G-quadruplex formation can be remotely induced by downstream transcription events that are thousands of base pairs away and suggested that a G- quadruplex-forming sequence can serve as a sensor or receiver to sense remote DNA tracking activity in response to the propagation of mechanical torsion in a DNA double helix.
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A C9orf72-CARM1 axis regulates lipid metabolism under glucose starvation-induced nutrient stress
Yang Liu,Tao Wang,Yon Ju Ji,Kenji Johnson,Hong-he Liu,Kaitlin Johnson,Scott Bailey,Yongwon Suk,Yu Ning Lu,Mingming Liu,Jiou Wang +10 more
TL;DR: Results reveal a C9orf72-CARM1 axis in the control of stress-induced lipid metabolism and implicates epigenetic dysregulation in relevant human diseases.
Journal ArticleDOI
C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly.
Tao Wang,Hong-he Liu,Kie Itoh,Sungtaek Oh,Liang Zhao,Daisuke Murata,Hiromi Sesaki,Thomas Hartung,Chan Hyun Na,Jiou Wang +9 more
TL;DR: In this article, a mitochondrial inner-membrane-associated protein regulating cellular energy homeostasis via its critical role in the control of oxidative phosphorylation (OXPHOS) is reported.