Amitabh V. Nimonkar

TL;DR: Two of the core machineries that initiate recombinational DNA repair in human cells are established: Bloom helicase and DNA2 nuclease, and the complex comprising MRE11, RAD50, and NBS1 (MRN).

TL;DR: It is shown that DNA ends resected by hExo1 and BLM are used by human Rad51, but not its yeast or bacterial counterparts, to promote homologous DNA pairing, and provides biochemical evidence for a role of BLM and Exo1 in the initiation of recombinational DNA repair.

TL;DR: It is proposed that ZRANB3 maintains genomic stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events.

TL;DR: It is concluded that Rad52 participates in second-end capture by annealing a resected DNA break, complexed with RPA, to the joint molecule product of single-end invasion event, supporting a role for Rad52-promoted annealed in the formation of Holliday junctions in DSB repair.

TL;DR: It is demonstrated that translocation by Tid1 on DNA can result in disruption of three-stranded DNA structures and may be of critical importance for DNA repair and chromosome dynamics.