S
Stephen C. Kowalczykowski
Researcher at University of California, Davis
Publications - 225
Citations - 25765
Stephen C. Kowalczykowski is an academic researcher from University of California, Davis. The author has contributed to research in topics: DNA & Homologous recombination. The author has an hindex of 87, co-authored 220 publications receiving 24327 citations. Previous affiliations of Stephen C. Kowalczykowski include University of California & University of Oregon.
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Journal ArticleDOI
Biochemistry of homologous recombination in Escherichia coli.
TL;DR: This review focuses on the biochemical mechanisms underlying these steps, with particular emphases on the activities of the proteins involved and on the integration of these activities into likely biochemical pathways for recombination.
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Initiation of genetic recombination and recombination-dependent replication.
TL;DR: The initial steps common to these recombination and recombination-dependent replication processes are reviewed and the machinery of homologous recombination acts at these breaks and gaps to promote the events that result in gene recombination.
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BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repair
Amitabh V. Nimonkar,Jochen Genschel,Eri Kinoshita,Piotr Polaczek,Judith L. Campbell,Claire Wyman,Paul Modrich,Stephen C. Kowalczykowski +7 more
TL;DR: Two of the core machineries that initiate recombinational DNA repair in human cells are established: Bloom helicase and DNA2 nuclease, and the complex comprising MRE11, RAD50, and NBS1 (MRN).
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The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.
Xavier Veaute,Josette Jeusset,Christine Soustelle,Stephen C. Kowalczykowski,Eric Le Cam,Francis Fabre +5 more
TL;DR: It is shown that DNA strand exchange mediated in vitro by Rad51 is inhibited by Srs2, and that SRS2 disrupts Rad51 filaments formed on single-stranded DNA, providing an explanation for the anti-recombinogenic role of Srs1 in vivo and highlighting a previously unknown mechanism for recombination control.
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Purified human BRCA2 stimulates RAD51-mediated recombination
TL;DR: The purification of full-length BRCA2 is reported and it is shown that it both binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA).