An Zhou

TL;DR: SPC2-defective mice offer many possibilities for further delineating neuroendocrine precursor processing mechanisms and for exploring more fully the physiological roles of many neuropeptides and peptide hormones.

TL;DR: The proteomic signature of the ischemic-tolerant brain is characterized by increased abundance of transcriptional repressors, particularly polycomb group (PcG) proteins, which reveals a previously unknown mechanism of neuroprotection that involves gene repressor of the PcG family.

TL;DR: Perarin could protect MPP(+)-induced SH-SY5Y cells from apoptosis by regulating the function of UPS, as evidenced by promoting cell viability, improving morphological changes and reducing apoptotic rate.

TL;DR: The results suggested that GNA significantly inhibited the proliferation of several tumor cell lines in vitro and in vivo and might suggest that G NA inhibits tumor cell proliferation via apoptosis-induction and cell cycle arrest.

TL;DR: It is shown that absence of the proneuropeptide processing enzyme, CPE, in CPE knock‐out mice had a profound effect on memory, synaptic physiology, and the cytoarchitecture of the hippocampus in these animals, indicating that CPE is essential for the survival of adult hippocampal CA3 neurons to maintain normal cognitive function.