Journal ArticleDOI
Involvement of ubiquitin proteasome system in protective mechanisms of Puerarin to MPP+-elicited apoptosis
Yue-Fa Cheng,Guo-Qi Zhu,Mei Wang,Hui Cheng,An Zhou,Ning Wang,Nianbai Fang,Xun-Cui Wang,Xiao-Qiu Xiao,Zhi-Wu Chen,Qinglin Li +10 more
TLDR
Perarin could protect MPP(+)-induced SH-SY5Y cells from apoptosis by regulating the function of UPS, as evidenced by promoting cell viability, improving morphological changes and reducing apoptotic rate.About:
This article is published in Neuroscience Research.The article was published on 2009-01-01. It has received 81 citations till now. The article focuses on the topics: Puerarin & Programmed cell death.read more
Citations
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SH-SY5Y human neuroblastoma cell line: in vitro cell model of dopaminergic neurons in Parkinson's disease.
Hongrong Xie,Lin-sen Hu,Guoyi Li +2 more
TL;DR: Evaluating the human neuroblastoma SH-SY5Y cell line as an in vitro model of dopaminergic (DAergic) neurons for Parkinson's disease (PD) research and the effect of differentiation on this cell model found some differentiating agents afford SH- SY5Y cells with more potential for studying neurotoxicity and neuroprotection and are thus more relevant to experimental PD research.
Journal ArticleDOI
Puerarin: A Review of Pharmacological Effects
TL;DR: The beneficial effects of puerarin on the various medicinal purposes may be due to its wide spectrum of pharmacological properties such as vasodilation, cardioprotection, neuroprotection, antioxidant, anticancer, antiinflammation, alleviating pain, promoting bone formation, inhibiting alcohol intake, and attenuating insulin resistance.
Journal ArticleDOI
Radix Puerariae: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use
TL;DR: The current review is proposed to cover its traditional applications, pharmacological activities, pharmacokinetics, clinical efficacy, and potential herb–drug interactions aiming to fill in the information gaps of this herb for frontline practitioners.
Journal ArticleDOI
Quercetin protects rat liver against lead-induced oxidative stress and apoptosis
TL;DR: The data suggest that quercetin protects the rat liver from lead-induced injury by attenuating lipid peroxidation, renewing the activities of antioxidant enzymes and inhibiting apoptosis.
Journal ArticleDOI
Progress on the pharmacological research of puerarin: a review.
Shu-Yong Wei,Yi Chen,Xiao-Yu Xu +2 more
TL;DR: It is demonstrated that puerarin, the most important phytoestrogen extracted from Pueraria lobata(Willd.) Ohwi, has protecting functions on the cardiovascular system, nervous system, osteoporosis, liver injury, and inflammation in vivo and in vitro.
References
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α-Synuclein Is Degraded by Both Autophagy and the Proteasome *
TL;DR: It was found that not only is α-synuclein degraded by the proteasome, but it is also degraded by autophagy, which merits consideration as a potential therapeutic for Parkinsons disease, as it is designed for chronic use in humans.
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Alzheimer's Disease and Parkinson's Disease
TL;DR: The genetics of these familial forms of Alzheimer's and Parkinson's disease are examined to improve understanding of the pathobiology of the more common, sporadic forms of the diseases.
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Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.
Andreas Hartmann,Stéphane Hunot,Patrick P. Michel,Marie-Paule Muriel,Sheela Vyas,Baptiste Faucheux,A. Mouatt-Prigent,Hélène Turmel,Anu Srinivasan,Merle Ruberg,Gerard I. Evan,Yves Agid,Etienne C. Hirsch +12 more
TL;DR: In this paper, a positive correlation between the degree of neuronal loss in dopaminergic (DA) cell groups affected in the mesencephalon of Parkinson's disease patients and the percentage of caspase-3-positive neurons in these cell groups in control subjects was observed.
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Regulation of Autophagy by Extracellular Signal- Regulated Protein Kinases During 1-Methyl-4- Phenylpyridinium-Induced Cell Death
TL;DR: It is demonstrated that MPP(+) elicited increased autophagy in SH-SY5Y cells, and a role for extracellular signal-regulated protein kinase (ERK) signaling upstream of MPP+-elicited autophagic stress is implicate.
Journal ArticleDOI
Aggregated and monomeric α-synuclein bind to the S6′ proteasomal protein and inhibit proteasomal function
Heather Snyder,Kwame Mensah,Catherine Theisler,J.M. Lee,Andreas T Matouschek,Benjamin Wolozin +5 more
TL;DR: Binding studies demonstrate that both aggregated and monomeric α-synuclein selectively bind to the proteasomal protein S6′, a subunit of the 19 S cap, which suggests that proteasomesomal inhibition by aggregated α- synuclein could be mediated by interaction with S 6′.