Ana Baena

TL;DR: A unique case from the Colombian cohort of autosomal dominant Alzheimer’s disease is reported in which disease progression is substantially delayed despite unusually high amyloid plaque pathology, possibly related to a rare mutation in APOE3.

TL;DR: The present findings add to the growing evidence that molecular markers can characterize biological changes associated with AD in individuals who are still cognitively unimpaired by suggesting that tau PET imaging may be useful as a biomarker to distinguish individuals at high risk to develop the clinical symptoms of AD and to track disease progression.

TL;DR: Plasma NfL measurements increased with age in both groups, and began to differentiate carriers from non-carriers when aged 22 years (22 years before the estimated median age at mild cognitive impairment onset of 44 years), although the ability of plasma N fL to discriminate between carriers and non- carriers only reached high sensitivity close to the age of clinical onset.

TL;DR: This finding corroborates and refines previous results suggesting that disturbances of action‐related lexico‐semantic information in PD constitute a sui generis alteration manifested early in the course of the disease's physiopathology, and suggests that the grounding of action verbs on motor circuits could depend on fine‐grained intracategorical semantic distinctions.

TL;DR: Action appraisal deficits seem to constitute both a hallmark of naturalistic discourse processing in PD and a sensitive subject-level marker for patients with and without MCI, highlighting the relevance of ecological measures of embodied cognitive functions in the assessment of this population.