Justin S. Sanchez

TL;DR: A unique case from the Colombian cohort of autosomal dominant Alzheimer’s disease is reported in which disease progression is substantially delayed despite unusually high amyloid plaque pathology, possibly related to a rare mutation in APOE3.

TL;DR: In this paper, the authors detected initial cortical emergence of tauopathy near the rhinal sulcus in clinically normal people and tracked Aβ-associated spread of TAU from this site first to nearby neocortex of the temporal lobe and then to extratemporal regions.

TL;DR: In this paper, the locus coeruleus (LC) was identified as the initial site of hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU increases, TAU pathology emerges.

TL;DR: In this paper, both the replication of protein aggregates and their spreading throughout the brain are implicated in the progression of Alzheimer's disease (AD), but the rates of these processes are unknown.

TL;DR: In this article, a digital clock drawing test, DCTclock, was used to detect biomarkers of amyloid and tau pathology in clinically normal older adults (CN).