K
Kewei Chen
Researcher at Arizona State University
Publications - 567
Citations - 28922
Kewei Chen is an academic researcher from Arizona State University. The author has contributed to research in topics: Medicine & Dementia. The author has an hindex of 81, co-authored 448 publications receiving 25178 citations. Previous affiliations of Kewei Chen include Mayo Clinic & Good Samaritan Hospital.
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Journal ArticleDOI
Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E.
Eric M. Reiman,Richard J. Caselli,Lang S. Yun,Kewei Chen,Daniel Bandy,Satoshi Minoshima,Stephen N. Thibodeau,David Osborne +7 more
TL;DR: In late middle age, cognitively normal subjects who are homozygous for the epsilon 4 allele for apolipoprotein E have reduced glucose metabolism in the same regions of the brain as in patients with probable Alzheimer's disease.
Journal ArticleDOI
Thermosensory activation of insular cortex.
TL;DR: Using positron emission tomography, it is found contralateral activity correlated with graded cooling stimuli only in the dorsal margin of the middle/posterior insula in humans, which supports the proposal that central pain results from loss of the normal inhibition of pain by cold.
Journal ArticleDOI
Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia
Eric M. Reiman,Kewei Chen,Gene E. Alexander,Gene E. Alexander,Richard J. Caselli,Richard J. Caselli,Daniel Bandy,David Osborne,David Osborne,Ann M. Saunders,Ann M. Saunders,John Hardy,John Hardy +12 more
TL;DR: Young ε4 carriers and noncarriers did not differ significantly in their sex, age, educational level, clinical ratings, or neuropsychological test scores, and an aggregate surface-projection map was generated that compared regional PET measurements in the two groups.
Journal ArticleDOI
Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis
Yasser Iturria-Medina,Roberto C. Sotero,Paule-Joanne Toussaint,José María Mateos-Pérez,Alan C. Evans,Michael W. Weiner,Paul S. Aisen,Ronald C. Petersen,Clifford R. Jack,William J. Jagust,John Q. Trojanowki,Arthur W. Toga,Laurel A. Beckett,Robert C. Green,Andrew J. Saykin,John C. Morris,Leslie M. Shaw,Zaven S. Khachaturian,Greg Sorensen,Lew Kuller,Marc Raichle,Steven M. Paul,Peter Davies,Howard Fillit,Franz Hefti,Davie Holtzman,M. Marcel Mesulam,William Z. Potter,Peter J. Snyder,Adam Schwartz,T. J. Montine,Ronald G. Thomas,Michael C. Donohue,Sarah Walter,Devon Gessert,Tamie Sather,Gus Jiminez,Danielle J Harvey,Matt A. Bernstein,Nick C. Fox,Paul M. Thompson,Norbert Schuff,Bret J. Borowski,Jeff Gunter,M. L. Senjem,Prashanthi Vemuri,David T.W. Jones,Kejal Kantarci,Chad Ward,Robert A. Koeppe,Norm Foster,Eric M. Reiman,Kewei Chen,Chet Mathis,Susan M. Landau,Nigel J. Cairns,Erin Householder,Lisa Taylor-Reinwald,Virginia M.-Y. Lee,Magdalena Korecka,Michal J. Figurski,Karen Crawford,Scott C. Neu,Tatiana Foroud,Steven G. Potkin,Li Shen,Kelley Faber,Sungeun Kim,Kwangsik Nho,Leon J. Thal,Neil Buckholtz,M.S. Albert,Richard Frank,John K. Hsiao,Jeffrey Kaye,Joseph F. Quinn,Betty Lind,Raina Carter,Sara Dolen,Lon S. Schneider,Sonia Pawluczyk,Mauricio Beccera,Liberty Teodoro,Bryan M. Spann,James B. Brewer,Helen Vanderswag,Adam S. Fleisher,Judith L. Heidebrink,Joanne L. Lord,Sara S. Mason,Colleen S. Albers,David S. Knopman,Kris Johnson,Rachelle S. Doody,Javier Villanueva-Meyer,Munir Chowdhury,Susan Rountree,Mimi Dang,Yaakov Stern,Lawrence S. Honig,Karen L. Bell,Beau M. Ances,Maria Carroll,Sue Leon,Mark A. Mintun,Stacy Schneider,Angela Oliver,Daniel C. Marson,Randall Griffith,David Glenn Clark,David S. Geldmacher,John C. Brockington,Erik D. Roberson,Hillel Grossman,Effie M. Mitsis,Leyla de Toledo-Morrell,Raj C. Shah,Ranjan Duara,Daniel Varon,Maria T. Greig,Peggy Roberts,Marilyn S. Albert,Chiadi U. Onyike,Daniel D'Agostino,Stephanie Kielb,James E. Galvin,Brittany Cerbone,Christina A. Michel,Henry Rusinek,Mony J. de Leon,Lidia Glodzik,Susan De Santi,P. Murali Doraiswamy,Jeffrey R. Petrella,Terence Z. Wong,Steven E. Arnold,Jason Karlawish,David A. Wolk,Charles D. Smith,Greg Jicha,Peter A. Hardy,Partha Sinha,Elizabeth Oates,Gary R. Conrad,Oscar L. Lopez,MaryAnn Oakley,Donna M. Simpson,Anton P. Porsteinsson,Bonnie S. Goldstein,Kim Martin,Kelly M. Makino,M. Saleem Ismail,Connie Brand,Ruth A. Mulnard,Gaby Thai,Catherine Mc-Adams-Ortiz,Kyle B. Womack,Dana Mathews,Mary Quiceno,Ramon Diaz-Arrastia,Richard V. King,Myron F. Weiner,Kristen Martin-Cook,Michael D. Devous,Allan I. Levey,James J. Lah,Janet S. Cellar,Jeffrey M. Burns,Heather Anderson,Russell H. Swerdlow,Liana G. Apostolova,Kathleen Tingus,Ellen Woo,Daniel H.S. Silverman,Po H. Lu,George Bartzokis,Neill R. Graff-Radford,Francine Parfitt,Tracy Kendall,Heather Johnson,Martin R. Farlow,Annmarie Hake,Brandy R. Matthews,Scott Herring,Cynthia Hunt,Christopher H. van Dyck,Richard E. Carson,Martha G. MacAvoy,Howard Chertkow,Howard Bergman,Chris Hosein,Sandra E. Black,Bojana Stefanovic,Curtis Caldwell,Ging-Yuek Robin Hsiung,Howard Feldman,Benita Mudge,Michele Assaly,Andrew Kertesz,John Rogers,Charles Bernick,Donna Munic,Diana R. Kerwin,M.-Marsel Mesulam,Kristine Lipowski,Chuang Kuo Wu,Nancy Johnson,Carl H. Sadowsky,Walter Martinez,Teresa Villena,Raymond Scott Turner,Kathleen Johnson,Brigid Reynolds,Reisa A. Sperling,Keith A. Johnson,Gad A. Marshall,Meghan Frey,Barton Lane,Allyson Rosen,Jared R. Tinklenberg,Marwan N. Sabbagh,Christine M. Belden,Sandra Jacobson,Sherye A. Sirrel,Neil W. Kowall,Ronald J. Killiany,Andrew E. Budson,Alexander Norbash,Patricia Lynn Johnson,Joanne S. Allard,Alan J. Lerner,Paula Ogrocki,Leon Hudson,Evan Fletcher,Owen Carmichael,John M Olichney,Charles DeCarli,Smita Kittur,Michael Borrie,T. Y. Lee,Rob Bartha,Sterling C. Johnson,Sanjay Asthana,Cynthia M. Carlsson,Steven Potkin,Adrian Preda,Dana Nguyen,Pierre N. Tariot,Stephanie Reeder,Vernice Bates,Horacio Capote,Michelle Rainka,Douglas W. Scharre,Maria Kataki,Anahita Adeli,Earl A. Zimmerman,Dzintra Celmins,Alice D. Brown,Godfrey D. Pearlson,Karen Blank,Karen E. Anderson,Robert B. Santulli,Tamar J. Kitzmiller,Eben S. Schwartz,Kaycee M. Sink,Jeff D. Williamson,Pradeep Garg,Franklin Watkins,Brian R. Ott,Henry W. Querfurth,Geoffrey Tremont,Stephen Salloway,Paul Malloy,Stephen Correia,Howard J. Rosen,Bruce L. Miller,Jacobo Mintzer,Kenneth M. Spicer,David Bachman,Elizabether Finger,Stephen H. Pasternak,Irina Rachinsky,Dick J. Drost,Nunzio Pomara,Raymundo Hernando,Antero Sarrael,Susan K. Schultz,Laura L. Boles Ponto,Hyungsub Shim,Karen Elizabeth Smith,Norman R. Relkin,Gloria Chaing,Lisa Raudin,Amanda Smith,Kristin Fargher,Balebail Ashok Raj,Thomas C. Neylan,Jordan Grafman,Melissa Davis,Rosemary H Morrison,Jacqueline Hayes,Shannon Finley,Karl E. Friedl,Debra A. Fleischman,Konstantinos Arfanakis,Olga James,Dino Massoglia,J. Jay Fruehling,Sandra Harding,Elaine R. Peskind,Eric C. Petrie,Gail Li,Jerome A. Yesavage,Joy L. Taylor,Ansgar J. Furst +314 more
TL;DR: Imaging results suggest that intra-brain vascular dysregulation is an early pathological event during disease development, suggesting early memory deficit associated with the primary disease factors.
Journal ArticleDOI
Neuroanatomical correlates of externally and internally generated human emotion
Eric M. Reiman,Richard D. Lane,Geoffrey L. Ahern,Gary E. Schwartz,Richard J. Davidson,Karl J. Friston,Lang Sheng Yun,Kewei Chen +7 more
TL;DR: This study identified brain regions that participate in externally and internally generated human emotion, suggesting that these regions participate in aspects of emotion that do not depend on the nature of the emotional stimulus.