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Aaron P. Schultz
Researcher at Harvard University
Publications - 140
Citations - 9100
Aaron P. Schultz is an academic researcher from Harvard University. The author has contributed to research in topics: Cognitive decline & Dementia. The author has an hindex of 45, co-authored 140 publications receiving 6533 citations. Previous affiliations of Aaron P. Schultz include Haskins Laboratories & Brigham and Women's Hospital.
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Journal ArticleDOI
Tau positron emission tomographic imaging in aging and early Alzheimer disease
Keith A. Johnson,Aaron P. Schultz,Rebecca A. Betensky,J. Alex Becker,Jorge Sepulcre,Dorene M. Rentz,Dorene M. Rentz,Elizabeth C. Mormino,Jasmeer P. Chhatwal,Jasmeer P. Chhatwal,Rebecca E. Amariglio,Rebecca E. Amariglio,Kate V. Papp,Kate V. Papp,Gad A. Marshall,Gad A. Marshall,Mark W. Albers,Samantha Mauro,Lesley C. Pepin,Jonathan Alverio,Kelly Judge,Marlie Philiossaint,Timothy M. Shoup,Daniel Yokell,Bradford C. Dickerson,Teresa Gomez-Isla,Bradley T. Hyman,Neil Vasdev,Reisa A. Sperling +28 more
TL;DR: Detection of focal brain tau deposition during life could greatly facilitate accurate diagnosis of Alzheimer disease (AD), staging and monitoring of disease progression, and development of disease‐modifying therapies.
Journal ArticleDOI
Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease : A Longitudinal Study
Bernard Hanseeuw,Bernard Hanseeuw,Rebecca A. Betensky,Heidi I.L. Jacobs,Heidi I.L. Jacobs,Aaron P. Schultz,Jorge Sepulcre,J. Alex Becker,Danielle M. Cosio,Michelle E. Farrell,Yakeel T. Quiroz,Elizabeth C. Mormino,Elizabeth C. Mormino,Rachel F. Buckley,Rachel F. Buckley,Rachel F. Buckley,Kathryn V. Papp,Kathryn V. Papp,Rebecca A Amariglio,Rebecca A Amariglio,Ilse Dewachter,Ilse Dewachter,Adrian Ivanoiu,Adrian Ivanoiu,Willem Huijbers,Willem Huijbers,Trey Hedden,Gad A. Marshall,Gad A. Marshall,Jasmeer P. Chhatwal,Dorene M. Rentz,Dorene M. Rentz,Reisa A. Sperling,Reisa A. Sperling,Keith A. Johnson,Keith A. Johnson +35 more
TL;DR: amyloid accumulation was associated with subsequent tau accumulation, and this sequence of successive amyloid and tau changes in neocortex was found to mediate the association of initial amyloids with final cognition, measured 7 years later.
Journal ArticleDOI
Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden
Alexander Drzezga,J. Alex Becker,Koene R. A. Van Dijk,Aishwarya Sreenivasan,Tanveer Talukdar,Caroline Sullivan,Aaron P. Schultz,Jorge Sepulcre,Deepti Putcha,Doug Greve,Keith A. Johnson,Keith A. Johnson,Reisa A. Sperling,Reisa A. Sperling +13 more
TL;DR: The results indicate that disruption of functional connectivity and hypometabolism may represent early functional consequences of emerging molecular Alzheimer's disease pathology, evolving prior to clinical onset of dementia.
Journal ArticleDOI
Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report
Joseph F. Arboleda-Velasquez,Francisco Lopera,Michael J. O'Hare,Santiago Delgado-Tirado,Claudia Marino,Natalia Chmielewska,Natalia Chmielewska,Kahira L. Saez-Torres,Dhanesh Amarnani,Aaron P. Schultz,Reisa A. Sperling,Reisa A. Sperling,David Leyton-Cifuentes,Kewei Chen,Kewei Chen,Ana Baena,David Aguillon,Silvia Rios-Romenets,Margarita Giraldo,Edmarie Guzmán-Vélez,Daniel J. Norton,Daniel J. Norton,Enmanuelle Pardilla-Delgado,Arabiye Artola,Justin S. Sanchez,Juliana Acosta-Uribe,Juliana Acosta-Uribe,Matthew A. Lalli,Kenneth S. Kosik,Matthew J. Huentelman,Henrik Zetterberg,Kaj Blennow,Kaj Blennow,Rebecca Reiman,Ji Luo,Yinghua Chen,Pradeep Thiyyagura,Yi Su,Gyungah Jun,Marcus Naymik,Xiaowu Gai,Xiaowu Gai,Moiz Bootwalla,Jianling Ji,Jianling Ji,Lishuang Shen,John B Miller,Leo A. Kim,Pierre N. Tariot,Keith A. Johnson,Keith A. Johnson,Eric M. Reiman,Yakeel T. Quiroz,Yakeel T. Quiroz +53 more
TL;DR: A unique case from the Colombian cohort of autosomal dominant Alzheimer’s disease is reported in which disease progression is substantially delayed despite unusually high amyloid plaque pathology, possibly related to a rare mutation in APOE3.
Journal ArticleDOI
Synergistic Effect of β-Amyloid and Neurodegeneration on Cognitive Decline in Clinically Normal Individuals
Elizabeth C. Mormino,Rebecca A. Betensky,Trey Hedden,Aaron P. Schultz,Rebecca E. Amariglio,Rebecca E. Amariglio,Dorene M. Rentz,Dorene M. Rentz,Keith A. Johnson,Reisa A. Sperling,Reisa A. Sperling +10 more
TL;DR: The co-occurrence of Aβ and ND accelerates cognitive decline in CN individuals, and both factors are important to consider in upcoming secondary prevention trials targeting CN individuals at high risk for progression to the symptomatic stages of Alzheimer disease.