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Ana Griciuc
Researcher at Harvard University
Publications - 21
Citations - 1495
Ana Griciuc is an academic researcher from Harvard University. The author has contributed to research in topics: Microglia & Amyloid beta. The author has an hindex of 10, co-authored 20 publications receiving 1043 citations. Previous affiliations of Ana Griciuc include Protein Sciences & University of Tübingen.
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Journal ArticleDOI
Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta
Ana Griciuc,Alberto Serrano-Pozo,Antonio R. Parrado,Andrea N. Lesinski,Caroline Asselin,Kristina Mullin,Basavaraj Hooli,Se Hoon Choi,Bradley T. Hyman,Rudolph E. Tanzi +9 more
TL;DR: The minor allele of the CD33 SNP rs3865444, which confers protection against AD, was associated with reductions in both CD33 expression and insoluble amyloid beta 42 levels in AD brain and CD33 inhibition could represent a novel therapy for AD.
Journal ArticleDOI
TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease.
Ana Griciuc,Shaun R. Patel,Anthony N. Federico,Se Hoon Choi,Brendan J. Innes,Mary K. Oram,Gea Cereghetti,Gea Cereghetti,Danielle McGinty,Anthony Anselmo,Ruslan I. Sadreyev,Suzanne E. Hickman,Joseph El Khoury,Marco Colonna,Rudolph E. Tanzi +14 more
TL;DR: Crosstalk between CD33 and TREM2 includes regulation of the IL-1β/IL-1RN axis and a gene set in the "receptor activity chemokine" cluster that should facilitate AD therapeutics targeting these receptors.
Journal ArticleDOI
Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease
Cameron S. McAlpine,Cameron S. McAlpine,Joseph Park,Ana Griciuc,Eunhee Kim,Se Hoon Choi,Yoshiko Iwamoto,M. Kiss,Kathleen A. Christie,Claudio Vinegoni,Wolfram C. Poller,Wolfram C. Poller,John E. Mindur,Christopher T. Chan,Shun He,Henrike Janssen,Lai Ping Wong,Jeffrey Downey,Sumnima Singh,Atsushi Anzai,Florian Kahles,Mehdi Jorfi,Paolo Fumene Feruglio,Ruslan I. Sadreyev,Ralph Weissleder,Benjamin P. Kleinstiver,Matthias Nahrendorf,Rudolph E. Tanzi,Filip K. Swirski,Filip K. Swirski +29 more
TL;DR: In this paper, it was shown that interleukin-3 signalling from astrocytes to microglia is a key mediator of cross-talk and a node for therapeutic intervention in Alzheimer's disease.
Journal ArticleDOI
Inactivation of VCP/ter94 suppresses retinal pathology caused by misfolded rhodopsin in Drosophila.
TL;DR: These findings raise the possibility that excessive retrotranslocation and/or degradation of visual pigment is a primary cause of PN degeneration.
Journal ArticleDOI
The role of innate immune genes in Alzheimer's disease.
Ana Griciuc,Rudolph E. Tanzi +1 more
TL;DR: The role of the innate immune system and neuroinflammation in the pathogenesis of Alzheimer's disease, with an emphasis on microglial receptors CD33 and TREM2, was discussed in this article.