Ana Lako

TL;DR: It is shown that therapy acts on a specific subpopulation of exhausted CD8+ tumor-infiltrating lymphocytes (TILs) that retain polyfunctionality and are responsive to PD-1 blockade.

TL;DR: Regulators of lymphoid transcription and cellular energy metabolism are identified as drivers of venetoclax resistance in addition to the known involvement by BCL-2 family members, which were confirmed in patient samples.

TL;DR: Novel approaches are needed to improve outcomes in patients with squamous cell carcinoma of the oral cavity and promising rates of response in both arms are observed, supporting further neoadjuvant studies with these agents.

TL;DR: An integrated genomic and immunomics analysis of tumor samples from the same patients is performed to find potential predictive biomarkers of response to such combination therapy.

TL;DR: In this paper, the authors applied untargeted expansion sequencing (ExSeq) to the mouse brain, which yielded the readout of thousands of genes, including splice variants, revealing patterns across multiple cell types, layer-specific cell types across the mouse visual cortex, and the organization and position dependent states of tumor and immune cells in a human metastatic breast cancer biopsy.