M
Michal Slyper
Researcher at Broad Institute
Publications - 44
Citations - 4942
Michal Slyper is an academic researcher from Broad Institute. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 18, co-authored 33 publications receiving 2282 citations. Previous affiliations of Michal Slyper include Hebrew University of Jerusalem.
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Journal ArticleDOI
A revised airway epithelial hierarchy includes CFTR-expressing ionocytes
Daniel T. Montoro,Adam L. Haber,Moshe Biton,Moshe Biton,Vladimir Vinarsky,Brian M. Lin,Susan E. Birket,Feng Yuan,Sijia Chen,Hui Min Leung,Jorge Villoria,Noga Rogel,Grace Burgin,Alexander M. Tsankov,Avinash Waghray,Michal Slyper,Julia Waldman,Lan Nguyen,Danielle Dionne,Orit Rozenblatt-Rosen,Purushothama Rao Tata,Hongmei Mou,Manjunatha Shivaraju,Hermann Bihler,Martin Mense,Guillermo J. Tearney,Steven M. Rowe,John F. Engelhardt,Aviv Regev,Aviv Regev,Jayaraj Rajagopal +30 more
TL;DR: ‘pulse-seq’ is developed, combining scRNA-seq and lineage tracing, to show that tuft, neuroendocrine and ionocyte cells are continually and directly replenished by basal progenitor cells, establishing a new cellular narrative for airways disease.
Journal ArticleDOI
Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis
Christopher Smillie,Moshe Biton,Jose Ordovas-Montanes,Keri M. Sullivan,Grace Burgin,Daniel B. Graham,Rebecca H. Herbst,Rebecca H. Herbst,Noga Rogel,Michal Slyper,Julia Waldman,Malika Sud,Elizabeth Andrews,Gabriella Velonias,Adam L. Haber,Karthik A. Jagadeesh,Sanja Vickovic,Junmei Yao,Christine Stevens,Danielle Dionne,Lan T. Nguyen,Alexandra-Chloé Villani,Matan Hofree,Elizabeth A. Creasey,Hailiang Huang,Orit Rozenblatt-Rosen,John J. Garber,Hamed Khalili,A. Nicole Desch,Mark J. Daly,Mark J. Daly,Ashwin N. Ananthakrishnan,Alex K. Shalek,Ramnik J. Xavier,Aviv Regev,Aviv Regev +35 more
TL;DR: An atlas of 366,650 cells from the colon mucosa of 18 UC patients and 12 healthy individuals is generated, revealing 51 epithelial, stromal, and immune cell subsets, including BEST4+ enterocytes, microfold-like cells, and IL13RA2+IL11+ inflammatory fibroblasts, which are associated with resistance to anti-TNF treatment.
Journal ArticleDOI
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets.
Toni Delorey,Carly G. K. Ziegler,Graham Heimberg,Rachelly Normand,Yiming Yang,Yiming Yang,Asa Segerstolpe,Domenic Abbondanza,Stephen J. Fleming,Ayshwarya Subramanian,Daniel T. Montoro,Karthik A. Jagadeesh,Kushal K. Dey,Pritha Sen,Michal Slyper,Yered Pita-Juárez,Devan Phillips,Jana Biermann,Zohar Bloom-Ackermann,Nikolaos Barkas,Andrea Ganna,Andrea Ganna,James Gomez,Johannes C. Melms,Igor Katsyv,Erica Normandin,Erica Normandin,Pourya Naderi,Pourya Naderi,Yury Popov,Yury Popov,Siddharth S. Raju,Siddharth S. Raju,Sebastian Niezen,Sebastian Niezen,Linus T.-Y. Tsai,Katherine J. Siddle,Katherine J. Siddle,Malika Sud,Victoria M. Tran,Shamsudheen K. Vellarikkal,Shamsudheen K. Vellarikkal,Yiping Wang,Liat Amir-Zilberstein,Deepak Atri,Deepak Atri,Joseph M. Beechem,Olga R. Brook,Jonathan H. Chen,Jonathan H. Chen,Prajan Divakar,Phylicia Dorceus,Jesse M. Engreitz,Jesse M. Engreitz,Adam Essene,Donna M. Fitzgerald,Robin Fropf,Steven Gazal,Joshua Gould,John Grzyb,Tyler Harvey,Jonathan L. Hecht,Jonathan L. Hecht,Tyler Hether,Judit Jané-Valbuena,Michael Leney-Greene,Hui Ma,Hui Ma,Cristin McCabe,Daniel E. McLoughlin,Eric M. Miller,Christoph Muus,Christoph Muus,Mari Niemi,Robert F. Padera,Robert F. Padera,Robert F. Padera,Liuliu Pan,Deepti Pant,Carmel Pe’er,Jenna Pfiffner-Borges,Christopher J. Pinto,Jacob Plaisted,Jason Reeves,Marty Ross,Melissa Rudy,Erroll H. Rueckert,Michelle Siciliano,Alexander Sturm,Ellen Todres,Avinash Waghray,Sarah Warren,Shuting Zhang,Daniel R. Zollinger,Lisa A. Cosimi,Rajat M. Gupta,Rajat M. Gupta,Nir Hacohen,Nir Hacohen,Hanina Hibshoosh,Winston Hide,Alkes L. Price,Jayaraj Rajagopal,Purushothama Rao Tata,Stefan Riedel,Stefan Riedel,Gyongyi Szabo,Gyongyi Szabo,Gyongyi Szabo,Timothy L. Tickle,Patrick T. Ellinor,Deborah T. Hung,Deborah T. Hung,Pardis C. Sabeti,Richard M. Novak,Robert S. Rogers,Robert S. Rogers,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber,Z. Gordon Jiang,Z. Gordon Jiang,Dejan Juric,Mehrtash Babadi,Samouil L. Farhi,Benjamin Izar,James R. Stone,Ioannis S. Vlachos,Isaac H. Solomon,Orr Ashenberg,Caroline B. M. Porter,Bo Li,Bo Li,Alex K. Shalek,Alexandra-Chloé Villani,Orit Rozenblatt-Rosen,Orit Rozenblatt-Rosen,Aviv Regev +137 more
TL;DR: In this article, single-cell analysis of lung, heart, kidney and liver autopsy samples shows the molecular and cellular changes and immune response resulting from severe SARS-CoV-2 infection.
Journal ArticleDOI
Decoding human fetal liver haematopoiesis
Dorin-Mirel Popescu,Rachel A. Botting,Emily Stephenson,Kile Green,Simone Webb,Laura Jardine,Emily Calderbank,Krzysztof Polanski,Issac Goh,Mirjana Efremova,Meghan Acres,Daniel Maunder,Peter Vegh,Yorick Gitton,Jong-Eun Park,Roser Vento-Tormo,Zhichao Miao,Zhichao Miao,David Dixon,Rachel Rowell,David McDonald,James Fletcher,Elizabeth Poyner,Gary Reynolds,Michael W. Mather,Corina Moldovan,Lira Mamanova,Frankie Greig,Matthew D. Young,Kerstin B. Meyer,Steven Lisgo,Jaume Bacardit,Andrew Fuller,Ben Millar,Barbara A. Innes,Susan Lindsay,Michael J. T. Stubbington,Monika S. Kowalczyk,Bo Li,Orr Ashenberg,Marcin Tabaka,Danielle Dionne,Timothy L. Tickle,Timothy L. Tickle,Michal Slyper,Orit Rozenblatt-Rosen,Andrew Filby,Peter D. Carey,Alexandra-Chloé Villani,Alexandra-Chloé Villani,Anindita Roy,Aviv Regev,Aviv Regev,Alain Chédotal,Irene Roberts,Berthold Göttgens,Sam Behjati,Sam Behjati,Elisa Laurenti,Sarah A. Teichmann,Sarah A. Teichmann,Muzlifah Haniffa,Muzlifah Haniffa +62 more
TL;DR: A shift in the haemopoietic composition of fetal liver during gestation away from being predominantly erythroid, accompanied by a parallel change in differentiation potential of HSC/MPPs is demonstrated, which is validated to produce an integrated map of fetal liver haematopoiesis.
Journal ArticleDOI
A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors
Michal Slyper,Caroline B. M. Porter,Orr Ashenberg,Julia Waldman,Eugene Drokhlyansky,Isaac Wakiro,Isaac Wakiro,Christopher Smillie,Gabriela Smith-Rosario,Jingyi Wu,Jingyi Wu,Danielle Dionne,Sébastien Vigneau,Sébastien Vigneau,Judit Jané-Valbuena,Timothy L. Tickle,Sara Napolitano,Sara Napolitano,Mei-Ju Su,Mei-Ju Su,Anand G. Patel,Asa Karlstrom,Simon Gritsch,Masashi Nomura,Avinash Waghray,Satyen H. Gohil,Satyen H. Gohil,Alexander M. Tsankov,Alexander M. Tsankov,Livnat Jerby-Arnon,Ofir Cohen,Ofir Cohen,Johanna Klughammer,Yanay Rosen,Joshua Gould,Lan Nguyen,Matan Hofree,Peter J. Tramontozzi,Bo Li,Bo Li,Catherine J. Wu,Benjamin Izar,Rizwan Haq,Rizwan Haq,F. Stephen Hodi,Charles H. Yoon,Charles H. Yoon,Aaron N. Hata,Suzanne J. Baker,Mario L. Suvà,Mario L. Suvà,Raphael Bueno,Elizabeth H. Stover,Elizabeth H. Stover,Michael R. Clay,Michael A. Dyer,Michael A. Dyer,Natalie B. Collins,Natalie B. Collins,Natalie B. Collins,Ursula A. Matulonis,Nikhil Wagle,Bruce E. Johnson,Asaf Rotem,Asaf Rotem,Orit Rozenblatt-Rosen,Aviv Regev,Aviv Regev,Aviv Regev +68 more
TL;DR: A set of ready-to-use tools for profiling fresh and frozen clinical tumor samples using scRNA-Seq and snRNA- Seq facilitates the implementation of single-cell technologies in clinical settings and the construction ofsingle-cell tumor atlases.