Ana Lopez Ramirez

TL;DR: How autophagy upregulation may be a therapeutic strategy in a wide range of neurodegenerative conditions is described and possible pathways and druggable targets that may be suitable for this objective are considered.

TL;DR: It is shown that CALM modulates autophagy and alters clearance of tau, a protein which is a known autophagic substrate and which is causatively linked to AD, both in vitro and in vivo.

TL;DR: The current state of the field regarding SARS‐CoV‐2 research is presented and where research is needed is illuminated to better define the role both estrogen and metabolic comorbidities have in the COVID‐19 disease state, which can be key in screening potential therapeutic options as the search for effective treatments continue.

TL;DR: Zhang et al. as mentioned in this paper showed that estrogen could be a potential therapeutic target promoting cell protection against SARS-CoV-2 infection in the COVID-19 case.

TL;DR: In this article , the authors evaluated the autophagy mechanisms involved in neuroprotection induced by 17β-estradiol (E2) in a Tet-On inducible expression tauopathy cell model (EGFP-tau WT or with the P301L mutation, 0N4R isoform).