M
Mariana Pavel
Researcher at University of Cambridge
Publications - 17
Citations - 1668
Mariana Pavel is an academic researcher from University of Cambridge. The author has contributed to research in topics: Autophagy & Autophagosome. The author has an hindex of 10, co-authored 16 publications receiving 1187 citations. Previous affiliations of Mariana Pavel include Alexandru Ioan Cuza University & Grigore T. Popa University of Medicine and Pharmacy.
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Journal ArticleDOI
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities
Fiona M. Menzies,Angeleen Fleming,Andrea Caricasole,Carla F. Bento,Stephen P. Andrews,Avraham Ashkenazi,Jens Füllgrabe,Anne Jackson,Maria Jimenez Sanchez,Cansu Karabiyik,Floriana Licitra,Ana Lopez Ramirez,Mariana Pavel,Claudia Puri,Maurizio Renna,Thomas Ricketts,Lars Schlotawa,Mariella Vicinanza,Hyeran Won,Ye Zhu,John Skidmore,David C. Rubinsztein +21 more
TL;DR: How autophagy upregulation may be a therapeutic strategy in a wide range of neurodegenerative conditions is described and possible pathways and druggable targets that may be suitable for this objective are considered.
Journal ArticleDOI
Polyglutamine tracts regulate beclin 1-dependent autophagy
Avraham Ashkenazi,Carla F. Bento,Thomas Ricketts,Mariella Vicinanza,Farah H. Siddiqi,Mariana Pavel,Ferdinando Squitieri,Maarten C. Hardenberg,Sara Imarisio,Fiona M. Menzies,David C. Rubinsztein +10 more
TL;DR: A specific function for a wild-type polyQ tract that is abrogated by a competing longer polyQ mutation in a disease protein is described, and a deleterious function of such mutations distinct from their propensity to aggregate is identified.
Journal ArticleDOI
Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis
Mariana Pavel,Maurizio Renna,Maurizio Renna,So Jung Park,Fiona M. Menzies,Thomas Ricketts,Jens Füllgrabe,Avraham Ashkenazi,Rebecca A. Frake,Alejandro Carnicer Lombarte,Carla F. Bento,Kristian Franze,David C. Rubinsztein +12 more
TL;DR: It is reported that autophagy is compromised in contact-inhibited cells in 2D or 3D-soft extracellular matrix cultures, in which YAP/TAZ fail to co-transcriptionally regulate the expression of myosin-II genes, resulting in the loss of F-actin stress fibers, which impairs autophagosome formation.
Journal ArticleDOI
Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis.
Xiaoting Wu,Angeleen Fleming,Thomas Ricketts,Mariana Pavel,Herbert W. Virgin,Fiona M. Menzies,David C. Rubinsztein +6 more
TL;DR: A novel route whereby this plasma membrane-resident receptor is degraded by autophagy, via uptake into ATG16L1-positive autophagosome-precursor vesicles is defined, which may have relevance for diverse disease conditions, like Alzheimer's Disease or Crohn's Disease, associated with altered Autophagy.
Journal ArticleDOI
CCT complex restricts neuropathogenic protein aggregation via autophagy
Mariana Pavel,Sara Imarisio,Fiona M. Menzies,Maria Jimenez-Sanchez,Farah H. Siddiqi,Xiaoting Wu,Maurizio Renna,Cahir J. O'Kane,Damian C. Crowther,Damian C. Crowther,David C. Rubinsztein +10 more
TL;DR: It is shown that CCT integrity is essential for autophagosome degradation in cells or Drosophila and this phenomenon is orchestrated by the actin cytoskeleton and implicate autophagy defects in diseases with compromised CCT complex activity.