John Skidmore

TL;DR: How autophagy upregulation may be a therapeutic strategy in a wide range of neurodegenerative conditions is described and possible pathways and druggable targets that may be suitable for this objective are considered.

TL;DR: The research leading to breakthroughs in PPI inhibition is described and the existence of groups of structurally related PPIs within the PPI target class is highlighted to illustrate the research strategies that have proved most useful.

TL;DR: The term autophagy encompasses different pathways that route cytoplasmic material to lysosomes for degradation and includes macroautophagy, chaperone-mediated autophathy, and microautophathy as discussed by the authors .

TL;DR: A highly diastereoselective bifunctional organocatalyst controlled Michael addition, a nitro-Mannich/lactamization cascade, a furan N-acyliminium cyclisation, a sequential alkyne RCM/syn-reduction and an alkene RCM has allowed a 19 step, highly stereoselectives synthesis of (-)-nakadomarin A.

TL;DR: In this article, a 15-mer or 20-mer poly-L-leucine bound to a PEG-based support was used as an immobilised catalysts in a fixed-bed reactor.