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Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

Fiona M. Menzies, +21 more
- 08 Mar 2017 - 
- Vol. 93, Iss: 5, pp 1015-1034
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TLDR
How autophagy upregulation may be a therapeutic strategy in a wide range of neurodegenerative conditions is described and possible pathways and druggable targets that may be suitable for this objective are considered.
About: 
This article is published in Neuron.The article was published on 2017-03-08 and is currently open access. It has received 786 citations till now. The article focuses on the topics: Autophagy & Neurodegeneration.

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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Lorenzo Galluzzi, +186 more
- 23 Jan 2018 - 
TL;DR: The Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives.
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

Effects of Intermittent Fasting on Health, Aging, and Disease

Rafael de Cabo, +1 more
- 25 Dec 2019 - 
TL;DR: Effects of Intermittent Fasting on Health and Aging evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base fasting.
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The proteostasis network and its decline in ageing.

Mark S. Hipp, +2 more
- 01 Jul 2019 - 
TL;DR: The possibilities of pharmacological augmentation of the capacity of proteostasis networks hold great promise for delaying the onset of age-related pathologies associated with proteome deterioration and for extending healthspan.
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Neuronal Cell Death.

Michael Fricker, +4 more
- 01 Apr 2018 - 
TL;DR: Which forms of cell death occur in stroke and Alzheimer's disease are reassess, and why it has been so difficult to pinpoint the type of neuronal death involved is discussed.
References
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mTOR Signaling in Growth Control and Disease

Mathieu Laplante, +1 more
TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.
Journal ArticleDOI

mTOR signaling in growth control and disease.

Mathieu Laplante, +1 more
- 13 Apr 2012 - 
TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.
Journal ArticleDOI

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim, +3 more
- 01 Feb 2011 - 
TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.
Journal ArticleDOI

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Tohru Kitada, +8 more
- 09 Apr 1998 - 
TL;DR: Mutations in the newly identified gene appear to be responsible for the pathogenesis of Autosomal recessive juvenile parkinsonism, and the protein product is named ‘Parkin’.
Journal ArticleDOI

Mammalian neural stem cells.

Fred H. Gage
- 25 Feb 2000 - 
TL;DR: Before the full potential of neural stem cells can be realized, the authors need to learn what controls their proliferation, as well as the various pathways of differentiation available to their daughter cells.
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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