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Ana M. Rodríguez-Piñeiro
Researcher at University of Gothenburg
Publications - 33
Citations - 3331
Ana M. Rodríguez-Piñeiro is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Mucus & Mucin. The author has an hindex of 20, co-authored 32 publications receiving 2558 citations. Previous affiliations of Ana M. Rodríguez-Piñeiro include University of Vigo & University of Barcelona.
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Journal ArticleDOI
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system
Thaher Pelaseyed,Joakim H. Bergström,Jenny K. Gustafsson,Anna Ermund,George M. H. Birchenough,André Schütte,Sjoerd van der Post,Frida Svensson,Ana M. Rodríguez-Piñeiro,Elisabeth E. L. Nyström,Catharina Wising,Malin E. V. Johansson,Gunnar C. Hansson +12 more
TL;DR: The mucus and epithelial cells of the gastrointestinal tract are the primary gate keepers and controllers of bacterial interactions with the host immune system, but the understanding of this relationship is still in its infancy.
Journal ArticleDOI
The composition of the gut microbiota shapes the colon mucus barrier
Hedvig E. Jakobsson,Ana M. Rodríguez-Piñeiro,André Schütte,Anna Ermund,Preben Boysen,Mats Bemark,Mats Bemark,Felix Sommer,Fredrik Bäckhed,Gunnar C. Hansson,Malin E. V. Johansson +10 more
TL;DR: The study shows that bacteria and their community structure affect mucus barrier properties in ways that can have implications for health and disease and highlights that genetically identical animals housed in the same facility can have rather distinct microbiotas and barrier structures.
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Composition and functional role of the mucus layers in the intestine
Malin E. V. Johansson,Daniel Ambort,Thaher Pelaseyed,André Schütte,Jenny K. Gustafsson,Anna Ermund,Durai B. Subramani,Jessica Holmén-Larsson,Kristina A. Thomsson,Joakim H. Bergström,Sjoerd van der Post,Ana M. Rodríguez-Piñeiro,Henrik Sjövall,Malin Bäckström,Gunnar C. Hansson +14 more
TL;DR: The mucus of the small intestine has only one layer, whereas the large intestine has a two-layered mucus where the inner, attached layer has a protective function for the intestine, as it is impermeable to the luminal bacteria.
Journal ArticleDOI
Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization.
Malin E. V. Johansson,Hedvig E. Jakobsson,Jessica Holmén-Larsson,André Schütte,Anna Ermund,Ana M. Rodríguez-Piñeiro,Liisa Arike,Catharina Wising,Frida Svensson,Fredrik Bäckhed,Gunnar C. Hansson +10 more
TL;DR: Although the colon mucus organization of GF mice was similar to that of conventionally raised (Convr) mice, the GF inner mucus layer was penetrable to bacteria-sized beads, indicating that studies of mature microbe-mucus interactions should be conducted weeks after colonization.
Journal ArticleDOI
Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distribution.
Jessica M. Holmén Larsson,Kristina A. Thomsson,Ana M. Rodríguez-Piñeiro,Hasse Karlsson,Gunnar C. Hansson +4 more
TL;DR: The mouse intestinal mucus is mainly made up by the gel-forming Muc2 mucin and the stomach surface mucus Muc5ac, both extensively O-glycosylated, and the mucin glycans are likely very important for the selection and maintenance of a stable intestinal flora.