S
Sjoerd van der Post
Researcher at University of Gothenburg
Publications - 27
Citations - 2545
Sjoerd van der Post is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Mucin & Mucus. The author has an hindex of 15, co-authored 27 publications receiving 1892 citations. Previous affiliations of Sjoerd van der Post include Washington University in St. Louis.
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Journal ArticleDOI
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system
Thaher Pelaseyed,Joakim H. Bergström,Jenny K. Gustafsson,Anna Ermund,George M. H. Birchenough,André Schütte,Sjoerd van der Post,Frida Svensson,Ana M. Rodríguez-Piñeiro,Elisabeth E. L. Nyström,Catharina Wising,Malin E. V. Johansson,Gunnar C. Hansson +12 more
TL;DR: The mucus and epithelial cells of the gastrointestinal tract are the primary gate keepers and controllers of bacterial interactions with the host immune system, but the understanding of this relationship is still in its infancy.
Journal ArticleDOI
Composition and functional role of the mucus layers in the intestine
Malin E. V. Johansson,Daniel Ambort,Thaher Pelaseyed,André Schütte,Jenny K. Gustafsson,Anna Ermund,Durai B. Subramani,Jessica Holmén-Larsson,Kristina A. Thomsson,Joakim H. Bergström,Sjoerd van der Post,Ana M. Rodríguez-Piñeiro,Henrik Sjövall,Malin Bäckström,Gunnar C. Hansson +14 more
TL;DR: The mucus of the small intestine has only one layer, whereas the large intestine has a two-layered mucus where the inner, attached layer has a protective function for the intestine, as it is impermeable to the luminal bacteria.
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A HUPO test sample study reveals common problems in mass spectrometry–based proteomics
Alexander W. Bell,Eric W. Deutsch,Catherine E. Au,Robert E. Kearney,Ron Beavis,Salvatore Sechi,Tommy Nilsson,John J.M. Bergeron,Thomas A. Beardslee,Thomas Chappell,Gavin Meredith,Peter J. Sheffield,Phillip Gray,Mahbod Hajivandi,Marshall Pope,Paul F. Predki,Majlinda Kullolli,Marina Hincapie,William S. Hancock,Wei Jia,Lina Song,Lei Li,Junying Wei,Bing Yang,Jinglan Wang,Wantao Ying,Yangjun Zhang,Yun Cai,Xiaohong Qian,Fuchu He,Helmut E. Meyer,Christian Stephan,Martin Eisenacher,Katrin Marcus,Elmar Langenfeld,Caroline May,Steve A. Carr,Rushdy Ahmad,Wenhong Zhu,Jeffrey W. Smith,Samir M. Hanash,Jason J. Struthers,Hong Wang,Qing Zhang,Yanming An,Radoslav Goldman,Elisabet Carlsohn,Sjoerd van der Post,Kenneth E. Hung,David A. Sarracino,Kenneth C. Parker,Bryan Krastins,Raju Kucherlapati,Sylvie Bourassa,Guy G. Poirier,Eugene A. Kapp,Heather Patsiouras,Robert L. Moritz,Richard J. Simpson,Benoit Houle,Sylvie Laboissiere,Pavel Metalnikov,Vivian Nguyen,Tony Pawson,Catherine C. L. Wong,Daniel Cociorva,John R. Yates,Michael J. Ellison,Ana Lopez-Campistrous,P. D. Semchuk,Yueju Wang,Peipei Ping,Giuliano Elia,Michael J. Dunn,Kieran Wynne,Angela K. Walker,John R. Strahler,Philip C. Andrews,Brian L. Hood,William L. Bigbee,Thomas P. Conrads,Derek Smith,Christoph H. Borchers,Gilles A. Lajoie,Sean C. Bendall,Kaye D. Speicher,David W. Speicher,Masanori Fujimoto,Kazuyuki Nakamura,Young Ki Paik,Sang Yun Cho,Min-Seok Kwon,Hyoung Joo Lee,Seul Ki Jeong,An Sung Chung,Christine A. Miller,Rudolf Grimm,Katy Williams,Craig A. Dorschel,Jayson A. Falkner,Lennart Martens,Juan Antonio Vizcaíno +101 more
TL;DR: Central analysis determined missed identifications, environmental contamination, database matching and curation of protein identifications as sources of problems in liquid chromatography–mass spectrometry–based proteomics.
Journal ArticleDOI
Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis.
Sjoerd van der Post,Karolina S. Jabbar,George M. H. Birchenough,Liisa Arike,Noreen Akhtar,Henrik Sjövall,Malin E. V. Johansson,Gunnar C. Hansson +7 more
TL;DR: Core mucus structural components were reduced in active UC, and alterations were associated with attenuation of the goblet cell secretory response to microbial challenge, but occurred independent of local inflammation.
Journal ArticleDOI
Function of the CysD domain of the gel-forming MUC2 mucin
Daniel Ambort,Sjoerd van der Post,Malin E. V. Johansson,Jenny Mackenzie,Elisabeth Thomsson,Ute Krengel,Gunnar C. Hansson +6 more
TL;DR: Observations suggest that CysD domains act as non-covalent cross-links in the MUC2 gel, thereby determining the pore sizes of the mucus.